N-carbethoxyphthalimide

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Names

[ CAS No. ]:
22509-74-6

[ Name ]:
N-carbethoxyphthalimide

[Synonym ]:
2H-Isoindole-2-carboxylic acid, 1,3-dihydro-1,3-dioxo-, ethyl ester
1,3-Dihydro-1,3-dioxo-2H-isoindole-2-carboxylic acid,ethyl ester
Ethyl N-phthaloylcarbamate
Ethyl 1,3-dioxo-2-isoindolinecarboxylate
Ethyl 1,3-dioxo-1,3-dihydro-2H-isoindole-2-carboxylate
EINECS 245-048-5
N-Carbethoxyphthalimide
2-Isoindolinecarboxylic acid,1,3-dioxo-,ethyl ester
T56 BVNVJ CVO2
Phthalimide-N-carbethoxy
MFCD00005893
N-carbethoxy-phthalimide
Ethyl phthalimide-N-carboxylate
N-Carboethoxyphthalimide
N-Ethoxycarbonylphthalimide
2H-Isoindole-2-carboxylic acid,1,3-dihydro-1,3-dioxo-,ethyl ester
1,3-Dioxo-1,3-dihydro-isoindole-2-c; arboxylic acid ethyl ester
Nefkin's reagent
1,3-Dioxo-1,3-dihydro-isoindole-2-carboxylic acid ethyl ester

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
353.9±25.0 °C at 760 mmHg

[ Melting Point ]:
90-92 °C(lit.)

[ Molecular Formula ]:
C11H9NO4

[ Molecular Weight ]:
219.193

[ Flash Point ]:
167.8±23.2 °C

[ Exact Mass ]:
219.053162

[ PSA ]:
63.68000

[ LogP ]:
1.15

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.595

[ Storage condition ]:
0-6°C

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NR3459500
CHEMICAL NAME :
2-Isoindolinecarboxylic acid, 1,3-dioxo-, ethyl ester
CAS REGISTRY NUMBER :
22509-74-6
BEILSTEIN REFERENCE NO. :
0196340
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C11-H9-N-O4
MOLECULAR WEIGHT :
219.21
WISWESSER LINE NOTATION :
T56 BVNVJ CVO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APJUA8 Acta Pharmaceutica Jugoslavica. (FDH, Masarykova 2, 41000 Zagreb, Yugoslavia) V.1-41, 1951-1991. Volume(issue)/page/year: 6,27,1956

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22-S24/25-S36/37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NR3459500

[ HS Code ]:
29251995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethyl chloroformate
  • Potassium phthalimide

DownStream

  • TERT-BUTYL (1S,9S)-6,10-DIOXO-9-PHTHALIMIDOOCTAHYDROPYRIDAZO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLATE
  • 4-(Phthalimide)cyclohexanol
  • 4-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)butanoic acid
  • N-phthaloyl-L-glutamic acid
  • Benzoic acid,4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-
  • 2H-Isoindole-2-aceticacid, a-(3-amino-3-oxopropyl)-1,3-dihydro-1,3-dioxo-,(aS)-
  • 3-PHTHALIMIDOPROPIONIC ACID
  • 6-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-hexanoic
  • pht-ala-oh
  • PHT-DL-VAL-OH

Preparation


Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Tetrahedron 49 , 13, (1993)


More Articles

Related Compounds

  • N,N'-bis[2-(3,4-dimethoxyphenyl)ethyl]-N,N'-dimethylpropane-1,3-diamine
  • N-octanoyl benzotriazole
  • N-[4-[(6-chloro-[1,3]dioxolo[4,5-b]acridin-10-yl)amino]-3-methoxyphenyl]methanesulfonamide
  • N-(diaminomethylidene)pyrrolidine-1-carboximidamide,hydrochloride
  • N-phenyl-[1,3]dioxolo[4,5-b]acridin-10-amine
  • N-[bis(diethylamino)silyl]-N-ethylethanamine
  • 9-phenyl-7-(tetrahydrofuran-2-ylmethyl)pyrido[4,3-d][1,2,4]triazolo[1,5-a]pyrimidin-8(7H)-one
  • 9-phenyl-7-(pyridin-3-ylmethyl)pyrido[4,3-d][1,2,4]triazolo[1,5-a]pyrimidin-8(7H)-one
  • 7-[2-(4-methoxyphenyl)ethyl]-9-phenylpyrido[4,3-d][1,2,4]triazolo[1,5-a]pyrimidin-8(7H)-one
  • 7-[2-(3,4-dimethoxyphenyl)ethyl]-9-phenylpyrido[4,3-d][1,2,4]triazolo[1,5-a]pyrimidin-8(7H)-one
  • 7-cyclopentyl-9-phenylpyrido[4,3-d][1,2,4]triazolo[1,5-a]pyrimidin-8(7H)-one
  • 7-[3-(methoxymethyl)-1H-1,2,4-triazol-5-yl]-9-phenylpyrido[4,3-d][1,2,4]triazolo[1,5-a]pyrimidin-8(7H)-one
  • 7-(2-hydroxyethyl)-2-methyl-9-phenylpyrido[4,3-d][1,2,4]triazolo[1,5-a]pyrimidin-8(7H)-one
  • 2-methyl-9-phenyl-7-(pyridin-2-ylmethyl)pyrido[4,3-d][1,2,4]triazolo[1,5-a]pyrimidin-8(7H)-one
  • 7-(4-methoxyphenethyl)-2-methyl-9-phenylpyrido[4,3-d][1,2,4]triazolo[1,5-a]pyrimidin-8(7H)-one
  • 2-methyl-9-phenyl-7-(4H-1,2,4-triazol-4-yl)pyrido[4,3-d][1,2,4]triazolo[1,5-a]pyrimidin-8(7H)-one
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