Bacitracin A1 (9CI)

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Names

[ Name ]:
Bacitracin A1 (9CI)

[Synonym ]:
Verrucarin A,7'-deoxo-2'-deoxy-2',3'-epoxy-3-hydroxy-7'-(1-hydroxyethyl)-,(2'S,3S,3'R,7'R(R))
baccharinoid B12
(2'S,3S,3'R,7'R(R))-7'-Deoxo-2'-deoxy-2',3'-epoxy-3-hydroxy-7'-(1-hydroxyethyl)verrucarin A
Solu-Tracin 50

Chemical & Physical Properties

[ Density]:
1.43 g/cm3

[ Boiling Point ]:
1755.5ºC at 760 mmHg

[ Molecular Formula ]:
C₆₆H₁₀₃N₁₇O₁₆S

[ Molecular Weight ]:
1422.69000

[ Flash Point ]:
1015.5ºC

[ Exact Mass ]:
1421.75000

[ PSA ]:
556.17000

[ LogP ]:
3.72410

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CP0350000

CHEMICAL NAME :: Bacitracin A

CAS REGISTRY NUMBER :: 22601-59-8

LAST UPDATED :: 199512

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C66-H103-N17-O16-S

MOLECULAR WEIGHT :: 1422.92

WISWESSER LINE NOTATION :: T5N CS AUTJ BYZY2 EVMY1Y&&VMY2VQVMYY2&&VM-WT-23-VM DVM GVM JVM MVM QVMTJ C3Z FY2 I1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 158 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity)

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 6,417,1951 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 474 mg/kg/3D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 6,417,1951

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Validation of a quantitative HPLC method for bacitracin and bacitracin zinc using EDTA as a mobile-phase modifier.

J. Pharm. Biomed. Anal. 70 , 619-23, (2012)

Any product marketed in the United States and labeled bacitracin must comply with the tests, procedures, and acceptance criteria in the relevant monograph published in the US Pharmacopeia (USP). The t...

Dereplicating nonribosomal peptides using an informatic search algorithm for natural products (iSNAP) discovery.

Proc. Natl. Acad. Sci. U. S. A. 109(47) , 19196-201, (2012)

Nonribosomal peptides are highly sought after for their therapeutic applications. As with other natural products, dereplication of known compounds and focused discovery of new agents within this class...

Affinity capillary electrophoresis study of the linkage existing between proton and zinc ion binding to bacitracin A1.

Electrophoresis 24(5) , 801-7, (2003)

Measurements by capillary electrophoresis (CE) of bacitracin A(1) effective mobility at different pH values permitted to estimate the five acidic dissociation constants and the Stokes radii at differe...