(R)-(+)-4-Hydroxy-2-pyrrolidinone

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Names

[ CAS No. ]:
22677-21-0

[ Name ]:
(R)-(+)-4-Hydroxy-2-pyrrolidinone

[Synonym ]:
(R)-(+)-4-Hydroxy-2-pyrrolidinone
(4R)-4-hydroxypyrrolidin-2-one
4(R)-hydroxy-2-pyrrolidinone
(R)-4-Hydroxypyrrolidin-2-one
(4R)-4-Hydroxypyrrolidin-2-on
(R)-4-Hydroxy-2-pyrrolidone
RHPD
(R)-4-HYDROXY-2-PYRROLIDINONE
MFCD00273364
(4S)-4-hydroxypyrrolidin-2-one
(4R)-4-hydroxy-2-pyrrolidone
(4S)-4-Hydroxy-2-pyrrolidinone
(S)-4-Hydroxy-pyrrolidine-2-one
(S)-4-Hydroxy-2-pyrrolidinone
(4R)-4-Hydroxy-2-pyrrolidinone
2-Pyrrolidinone, 4-hydroxy-, (4S)-
2-Pyrrolidinone, 4-hydroxy-, (4R)-

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
363.6±35.0 °C at 760 mmHg

[ Melting Point ]:
156-160ºC

[ Molecular Formula ]:
C4H7NO2

[ Molecular Weight ]:
101.104

[ Flash Point ]:
173.7±25.9 °C

[ Exact Mass ]:
101.047676

[ PSA ]:
49.33000

[ LogP ]:
-2.55

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.513

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933790090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Chloro-3-hydroxybutyric acid ethyl ester

DownStream

  • DL-γ-Amino-β-hydroxybutyric acid

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Articles

Phase diagram of (R)- and (S)-4-hydroxy-2-pyrrolidone mixtures: a new case of a conglomerate-forming system.

J. Pharm. Sci. 82(7) , 758-60, (1993)

The phase diagram of (R)- and (S)-4-hydroxy-2-pyrrolidone presents a conglomerate in the racemic mixture. The enthalpy of melting extrapolated by the Schröder-van Laar-Le Chatelier equation [change in...


More Articles

Related Compounds

  • (r)-(+)-1-boc-4-hydroxy-2-pyrrolidinone
  • (r)-(+)-1-benzyl-4-hydroxy-2-pyrrolidinone
  • (R)-(+)-HA-966
  • (R)-(+)-4-[2-(Diphenylphosphino)-1-naphthalenyl]-N-[(R)-1-phenylethoxy]phthalazine, min. 97 (R,R)-O-PINAP
  • (R)-(+)-4-[2-(Diphenylphosphino)-1-naphthalenyl]-N-[(S)-1-phenylethyl]-1-phthalazinamine
  • (R)-(+)-4-(2,3-dichlorophenyl)-1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-3-pyridinecarboxylic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • 3-bromo-4-{[1-(5-methyl-1-phenyl-1H-pyrazole-4-carbonyl)pyrrolidin-3-yl]oxy}pyridine