2H-1,4-BENZODIAZEPIN-2-ONE, 1,3-DIHYDRO-5-PHENYL-7-(TRIFLUOROMETHYL)-

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Names

[ CAS No. ]:
2285-16-7

[ Name ]:
2H-1,4-BENZODIAZEPIN-2-ONE, 1,3-DIHYDRO-5-PHENYL-7-(TRIFLUOROMETHYL)-

[Synonym ]:
5-Phenyl-7-trifluormethyl-2-oxo-1.2-dihydro-1.4-benzodiazepin
5-Phenyl-7-trifluormethyl-1.3-dihydro-2H-1.4-benzodiazepin-2-on
5-Phenyl-7-trifluormethyl-2,3-dihydro-1H-<1,4>-benzodiazepin-2-on
1,3-Dihydro-5-phenyl-7-trifluoromethyl-2H-1,4-benzodiazepin-2-one
Ro 5-2904
7-trifluoro-methyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one
7-Trifluormethyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-on

Chemical & Physical Properties

[ Density]:
1.34g/cm3

[ Boiling Point ]:
421.6ºC at 760 mmHg

[ Molecular Formula ]:
C16H11F3N2O

[ Molecular Weight ]:
304.26700

[ Flash Point ]:
208.8ºC

[ Exact Mass ]:
304.08200

[ PSA ]:
41.46000

[ LogP ]:
3.06850

[ Vapour Pressure ]:
2.57E-07mmHg at 25°C

[ Index of Refraction ]:
1.586

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DF2625000
CHEMICAL NAME :
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-5-phenyl-7-(trifluoromethyl)-
CAS REGISTRY NUMBER :
2285-16-7
BEILSTEIN REFERENCE NO. :
0758865
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H11-F3-N2-O
MOLECULAR WEIGHT :
304.29
WISWESSER LINE NOTATION :
T67 GMV JN IHJ CXFFF KR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
204 mg/kg
TOXIC EFFECTS :
Behavioral - anticonvulsant
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 154,131,1965

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • N'-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-[(4-morpholin-4-ylthian-4-yl)methyl]oxamide
  • N-{1-[5-fluoro-6-(4-fluorophenyl)pyrimidin-4-yl]azetidin-3-yl}-N,1-dimethyl-1H-pyrazole-4-sulfonamide
  • N,1-dimethyl-N-{1-[3-(pyridin-3-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]azetidin-3-yl}-1H-pyrazole-5-carboxamide
  • 4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-({1-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]piperidin-4-yl}methoxy)pyrimidine
  • N-(5-chloro-2-methoxyphenyl)-N'-{[4-(morpholin-4-yl)thian-4-yl]methyl}ethanediamide
  • 4-({[6-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-yl]oxy}methyl)-N-(2-methylphenyl)piperidine-1-carboxamide
  • N,N-dimethyl-4-[3-(pyridin-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-1,4-diazepane-1-sulfonamide
  • N,1,5-trimethyl-N-{1-[3-(pyridin-3-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]azetidin-3-yl}-1H-pyrazole-3-carboxamide
  • N,2,5-Trimethyl-N-[1-(3-pyridin-3-yl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)azetidin-3-yl]pyrazole-3-carboxamide
  • 2-(1H-pyrazol-1-yl)-1-{4-[3-(pyridin-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-1,4-diazepan-1-yl}ethan-1-one
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