Benznidazole
Suppliers
Names
[ CAS No. ]:
22994-85-0
[ Name ]:
Benznidazole
[Synonym ]:
MFCD00243089
N-benzyl-2-(2-nitroimidazol-1-yl)acetamide
1H-Imidazole-1-acetamide,2-nitro-N-(phenylmethyl)-
Chemical & Physical Properties
[ Density]:
1.35g/cm3
[ Melting Point ]:
189-192ºC(lit.)
[ Molecular Formula ]:
C12H12N4O3
[ Molecular Weight ]:
260.24900
[ Exact Mass ]:
260.09100
[ PSA ]:
92.74000
[ LogP ]:
2.02180
[ Index of Refraction ]:
1.643
[ Storage condition ]:
-20℃
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NI3340000
- CHEMICAL NAME :
- Imidazole-1-acetamide, N-benzyl-2-nitro-
- CAS REGISTRY NUMBER :
- 22994-85-0
- BEILSTEIN REFERENCE NO. :
- 0551486
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C12-H12-N4-O3
- MOLECULAR WEIGHT :
- 260.28
- WISWESSER LINE NOTATION :
- T5N CNJ A1VM1R& BNW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 8 gm/kg
- SEX/DURATION :
- male 8 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 50 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 320,305,1994
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
26-36
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
NI3340000
[ HS Code ]:
2933290090
Customs
[ HS Code ]: 2933290090
[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Antimicrob. Agents Chemother. 56(11) , 5821-30, (2012)
Nitroheterocyclic prodrugs are used to treat infections caused by Trypanosoma cruzi and Trypanosoma brucei. A key component in selectivity involves a specific activation step mediated by a protein hom...
Vector Borne Zoonotic Dis. 13(3) , 181-7, (2013)
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and it affects as many as 10 million people in North and South America, where it represents a major public health problem. T. cruz...
PLoS Negl. Trop. Dis. 7(1) , e1965, (2013)
Immunosuppression, which has become an increasingly relevant clinical condition in the last 50 years, modifies the natural history of Trypanosoma cruzi infection in most patients with Chagas disease. ...