alpha-Amanitin

Suppliers

Names

[ Name ]:
alpha-Amanitin

[Synonym ]:
α-Amanitin,cyclo[L-Asparaginyl-4-hydroxy-L-proly-(R-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl]cyclic(4-8)-sulfide(R)-S-oxide
alpha-amanitin
MFCD00215842
EINECS 245-432-2
A-AMANITIN
AMANITIN,A

Chemical & Physical Properties

[ Density]:
1.57 g/cm3

[ Boiling Point ]:
1622.2ºC at 760 mmHg

[ Melting Point ]:
254-255ºC(lit.)

[ Molecular Formula ]:
C₃₉H₅₄N₁₀O₁₄S

[ Molecular Weight ]:
918.97000

[ Flash Point ]:
934.9ºC

[ Exact Mass ]:
918.35400

[ PSA ]:
400.09000

[ Index of Refraction ]:
1.694

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BD6195000

CHEMICAL NAME :: alpha-Amanitine

CAS REGISTRY NUMBER :: 23109-05-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 23

MOLECULAR FORMULA :: C39-H54-N10-O14-S

MOLECULAR WEIGHT :: 919.09

WISWESSER LINE NOTATION :: T C6 B5 R5-18--18-/MP& A K L 2BJ P& IM KS NVM QVN WVM C&VM F&VM I&VM L&VM O&VM&&TTTJ FQ KO P1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Mammal - cattle Liver

DOSE/DURATION :: 3 mg/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 56,289,1985

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H310-H330-H373

[ Precautionary Statements ]:
P260-P264-P280-P284-P301 + P310-P302 + P350

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+: Very toxic;

[ Risk Phrases ]:
R26/27/28

[ Safety Phrases ]:
36/37/39-45-36/37-28

[ RIDADR ]:
UN 3462 6

[ WGK Germany ]:
3

[ RTECS ]:
BD6195000

[ Packaging Group ]:
I

[ Hazard Class ]:
6.1(a)

Preparation

Articles

Arabidopsis RRP6L1 and RRP6L2 function in FLOWERING LOCUS C silencing via regulation of antisense RNA synthesis.

PLoS Genet. 10(9) , e1004612, (2014)

The exosome complex functions in RNA metabolism and transcriptional gene silencing. Here, we report that mutations of two Arabidopsis genes encoding nuclear exosome components AtRRP6L1 and AtRRP6L2, c...

Thyroid hormone increases bulk histones expression by enhancing translational efficiency.

Mol. Endocrinol. 29(1) , 68-75, (2014)

The expression of canonical histones is normally coupled to DNA synthesis during the S phase of the cell cycle. Replication-dependent histone mRNAs do not contain a poly(A) tail at their 3' terminus, ...

α-1-antitrypsin inhibits acute liver failure in mice.

Hepatology 59(6) , 2299-308, (2014)

Acute liver failure remains a critical clinical condition, with high mortality rates, and increased apoptosis of hepatocytes represents a key event in the cause of liver failure. Alpha-1-antitrypsin (...