alpha-Amanitin
Suppliers
Names
[ CAS No. ]:
23109-05-9
[ Name ]:
alpha-Amanitin
[Synonym ]:
α-Amanitin,cyclo[L-Asparaginyl-4-hydroxy-L-proly-(R-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl]cyclic(4-8)-sulfide(R)-S-oxide
alpha-amanitin
MFCD00215842
EINECS 245-432-2
A-AMANITIN
AMANITIN,A
Chemical & Physical Properties
[ Density]:
1.57 g/cm3
[ Boiling Point ]:
1622.2ºC at 760 mmHg
[ Melting Point ]:
254-255ºC(lit.)
[ Molecular Formula ]:
C39H54N10O14S
[ Molecular Weight ]:
918.97000
[ Flash Point ]:
934.9ºC
[ Exact Mass ]:
918.35400
[ PSA ]:
400.09000
[ Index of Refraction ]:
1.694
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BD6195000
- CHEMICAL NAME :
- alpha-Amanitine
- CAS REGISTRY NUMBER :
- 23109-05-9
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 23
- MOLECULAR FORMULA :
- C39-H54-N10-O14-S
- MOLECULAR WEIGHT :
- 919.09
- WISWESSER LINE NOTATION :
- T C6 B5 R5-18--18-/MP& A K L 2BJ P& IM KS NVM QVN WVM C&VM F&VM I&VM L&VM O&VM&&TTTJ FQ KO P1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Mammal - cattle Liver
- DOSE/DURATION :
- 3 mg/L
- REFERENCE :
- CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 56,289,1985
Safety Information
[ Symbol ]:
GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300-H310-H330-H373
[ Precautionary Statements ]:
P260-P264-P280-P284-P301 + P310-P302 + P350
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ Hazard Codes ]:
T+: Very toxic;
[ Risk Phrases ]:
R26/27/28
[ Safety Phrases ]:
36/37/39-45-36/37-28
[ RIDADR ]:
UN 3462 6
[ WGK Germany ]:
3
[ RTECS ]:
BD6195000
[ Packaging Group ]:
I
[ Hazard Class ]:
6.1(a)
Preparation
Articles
PLoS Genet. 10(9) , e1004612, (2014)
The exosome complex functions in RNA metabolism and transcriptional gene silencing. Here, we report that mutations of two Arabidopsis genes encoding nuclear exosome components AtRRP6L1 and AtRRP6L2, c...
Mol. Endocrinol. 29(1) , 68-75, (2014)
The expression of canonical histones is normally coupled to DNA synthesis during the S phase of the cell cycle. Replication-dependent histone mRNAs do not contain a poly(A) tail at their 3' terminus, ...
Hepatology 59(6) , 2299-308, (2014)
Acute liver failure remains a critical clinical condition, with high mortality rates, and increased apoptosis of hepatocytes represents a key event in the cause of liver failure. Alpha-1-antitrypsin (...