Lapatinib (GW572016)

Suppliers

Names

[ CAS No. ]:
231277-92-2

[ Name ]:
Lapatinib (GW572016)

[Synonym ]:
4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-
Lapatinib (2TsOH)
GW-2016
N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazolin-4-amine
N-{3-Chloro-4-[(3-fluorobenzyl) oxy]phenyl}-6-[5-({[2-(methanesulphonyl) ethyl]amino}methyl)-2-furyl]-4-quinazolinamine
Lapatinib [INN]
4-{[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]amino}-6-(5-{[(2-methanesulphonyl-ethyl)amino]methyl}-furan-2-yl)quinazoline
N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine
4-{[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]amino}-6-(5-{[(2-methansulfonyl-ethyl)amino]methyl}-furan-2-yl)quinazoline
N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methanesulphonyl)ethyl]amino}methyl)-furan-2-yl]-4-quinazolinamine
Tyverb
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine
N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]quinazolin-4-amine
Lapatinib
Tykerb

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
750.7±60.0 °C at 760 mmHg

[ Melting Point ]:
147 °C

[ Molecular Formula ]:
C29H26ClFN4O4S

[ Molecular Weight ]:
581.057

[ Flash Point ]:
407.8±32.9 °C

[ Exact Mass ]:
580.134705

[ PSA ]:
114.73000

[ LogP ]:
5.14

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.645

Safety Information

[ Hazard Codes ]:
T,F

[ Risk Phrases ]:
R10:Flammable. R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . R34:Causes burns. R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S36/37/39-S45-S24/25-S16

[ RIDADR ]:
UN 3275 6.1/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Aminoethyl methyl sulfone
  • 5-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-carbaldehyde
  • Lapatinib ditosylate hydrate
  • N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((2-(methylsulfonyl)ethylimino)methyl)furan-2-yl)quinazolin-4-amine
  • 2-Aminoethylmethylsulfone hydrochloride
  • 5-(4-((3-CHLORO-4-((3-FLUOROBENZYL)OXY)PHENYL)AMINO)QUINAZOLIN-6-YL)FURAN-2-CARBALDEHYDE HYDROCHLORIDE
  • N-((5-(4-chloroquinazolin-6-yl)furan-2-yl)Methyl)-2-(Methylsulfonyl)ethanamine
  • 3-Chloro-4-[(3-fluorobenzyl)oxy]aniline
  • N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine
  • 2-Formylfuran-5-boronic acid

DownStream

  • Lapatinib ditosylate hydrate

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • Lapatinib impurity P
  • Lapatinib (GW-572016) Ditosylate
  • Lapatinib 4-Fluoro Impurity
  • Lapatinib impurity K
  • Lapatinib impurity G
  • Lapatinib impurity F
  • 3-Bromo-4-oxiranyl-pyridine
  • 4,8-Diazaspiro[2.6]nonan-5-one
  • 4,8-Diazaspiro[2.6]nonan-7-one
  • Spiro[3.4]octan-2-ylmethanol
  • ({1-Azabicyclo[2.2.1]heptan-4-yl}methyl)(methyl)amine
  • 2-(3-Azabicyclo[3.1.1]heptan-3-yl)ethan-1-amine
  • N-methyl-1-(5-methyl-5-azaspiro[2.3]hexan-1-yl)methanamine
  • 3-Acetyl-6-methoxy-2-methylbenzonitrile
  • Methyl 2-[(2-methylpropyl)amino]-1,3-thiazole-4-carboxylate
  • 3-amino-1-(1H-1,2,3,4-tetrazol-5-yl)propan-1-ol
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