N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine

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Names

[ CAS No. ]:
231278-20-9

[ Name ]:
N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine

[Synonym ]:
4-[3-Chloro-4-(3-fluorobenzyloxy)phenylamino]-6-iodoquinazoline
N-[3-Chloro-4-(3-fluorobenzyloxy)-phenyl]-6-iodoquinazolin-4-amine
N-[3-chloro-4-(3-fluorobenzyloxy)phenylJ-6-iodoquinazolin-4-amine
4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-iodo-
N-{3-Chloro-4-[(3-fluorophenyl)-methoxy]-phenyl}-6-iodo-4-quinazolinamine
4-[3-Chloro-4-(3-fluorobenzyloxy)anilino]-6-iodoquinazoline
N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodoquinazolin-4-amine
N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-iodoquinazolin-4-aMine
[3-chloro-4-(3-fluorobenzyloxy)phenyl]-(6-iodoquinazolin-4-yl)amine
N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-iodo-4-quinazolinamine
N-{3-chloro-4-[(3-fluorophenyl)Methoxy]phenyl}-6-iodoquinazolin-4-aMine
Lapatinib Intermediate 2
N-[3-chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodo-quinazolin-4yl-amine
6-Iodo-4-[3-chloro-4-(3-fluorobenzyloxy)anilino]quinazoline
[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl](6-iodoquinazol
N-(3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine
N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methanesulphonyl) ethyl]amino}methyl)-2-furyl]-4-quinazolin amine ditosylate
(6-iodo-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-quinazolin-4-yl)amine

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
581.3±50.0 °C at 760 mmHg

[ Melting Point ]:
222-224°C

[ Molecular Formula ]:
C21H14ClFIN3O

[ Molecular Weight ]:
505.711

[ Flash Point ]:
305.4±30.1 °C

[ Exact Mass ]:
504.985413

[ PSA ]:
47.04000

[ LogP ]:
6.67

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.724

[ Storage condition ]:
-20°C Freezer

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S36/37/39

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Chloro-6-iodoquinazoline
  • 3-Chloro-4-[(3-fluorobenzyl)oxy]aniline
  • N(1)-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-N,N-dimethylformamidine
  • 2-Amino-5-iodobenzonitrile
  • 4-(3-Fluoro-benzyloxy)-phenylamine
  • 2-Chloro-4-nitrophenyl 3-fluorobenzyl ether
  • 3-chloro-4-(3-fluoro-benzyloxy)-phenylamine hydrochloride
  • 2-Chloro-4-nitrophenol
  • 1-(Bromomethyl)-3-fluorobenzene

DownStream

  • Lapatinib ditosylate hydrate
  • 5-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-carbaldehyde
  • Lapatinib (GW572016)
  • GW583340 DIHYDROCHLORIDE

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 4-(6-cyclopropylpyrimidin-4-yl)-N-(2,3-dimethoxyphenyl)piperazine-1-carboxamide
  • N-(4-(3-methoxypyrrolidin-1-yl)phenyl)benzamide
  • N-(4-(3-methoxypyrrolidin-1-yl)phenyl)thiophene-3-carboxamide
  • N-(4-(3-methoxypyrrolidin-1-yl)phenyl)-4-propyl-1,2,3-thiadiazole-5-carboxamide
  • 1-(4-butoxyphenyl)-3-(2-(5-methyl-6-oxopyrimidin-1(6H)-yl)ethyl)urea
  • N-(4-(3-methoxypyrrolidin-1-yl)phenyl)-1-(methylsulfonyl)piperidine-4-carboxamide
  • 2-(4-(isopropylthio)phenyl)-N-(4-(3-methoxypyrrolidin-1-yl)phenyl)acetamide
  • N-(4-(3-methoxypyrrolidin-1-yl)phenyl)-3-(4-(methylthio)phenyl)propanamide
  • N-[4-(3-Methoxypyrrolidin-1-YL)phenyl]-3-[4-(trifluoromethyl)phenyl]propanamide
  • 3-(3-Fluoro-4-methylphenyl)-N-[4-(3-methoxypyrrolidin-1-YL)phenyl]propanamide
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