(1R,2S)-2-Amino-1,2-diphenylethanol

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Names

[ Name ]:
(1R,2S)-2-Amino-1,2-diphenylethanol

[Synonym ]:
(1S,2R)-2-Amino-1,2-diphenylethanol
(1R,2S)-(-)-2-Amino-1,2-diphenylethanol
Benzeneethanol, β-amino-α-phenyl-, (αR,βS)-
2-diphenylethanol
Benzeneethanol, β-amino-α-phenyl-, (αS,βR)-
MFCD00074960
(1S,2R)-(+)-2-Amino-1,2-diphenylethanol
(1R,2S)-2-Amino-1,2-diphenylethanol

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
374.3±37.0 °C at 760 mmHg

[ Melting Point ]:
142-144 °C(lit.)

[ Molecular Formula ]:
C₁₄H₁₅NO

[ Molecular Weight ]:
213.28

[ Flash Point ]:
180.2±26.5 °C

[ Exact Mass ]:
213.115356

[ PSA ]:
46.25000

[ LogP ]:
2.28

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.622

[ Storage condition ]:
2~8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(1R,2S)-1,2-diphenyl-2-azidoethanol
Benzoin oxime
(R,R)-(+)-Hydrobenzoin
stilbene oxide
erythro-1,2-diphenyl-2-bromoethanol
2-amino-1,2-diphenyl-ethanol
Benzil
(E)-2-hydroxy-1,2-diphenylethan-1-one oxime
benzoin

DownStream

benzyl 3-bromo-2-oxo-5,6-diphenyloxazinan-2-ium-4-carboxylate
L-Homophenylalanine
(1R,2S)-(+)-2-AMINOCYCLOHEX-3-ENECARBOXYLICACIDHYDROCHLORIDE
(4S,5R)-CIS-4,5-DIPHENYLOXAZOLIDIN-2-ONE
benzoin
4-CHLORO-3-NITROBENZALDEHYDEOXIME
ETHYL 2-(((1S,2R)-2-HYDROXY-1,2-DIPHENYLETHYL)AMINO)ACETATE
(1S,2R)-2-Amino-1,2-diphenylethanol
(2R,3S)-Benzyl6-oxo-2,3-diphenylmorpholine-4-carboxylate

Preparation

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds.

Bioorg. Med. Chem. 17 , 3456-62, (2009)

We resolved 1,2-diphenylethylamine (DPEA) into its (S)- and (R)-enantiomer and used them as precursors for synthesis of (S)- and (R)-1-(1,2-diphenylethyl)piperidine, flexible homeomorphs of the NMDA c...

J.J. Masters et al.

J. Org. Chem. 56 , 5666, (1991)

J.J. Masters, L.S. Hegedus

J. Org. Chem. 58 , 4547, (1993)

(1R,2S)-2-Amino-1,2-diphenylethanol
(1R,2S)-2-amino-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)propan-1-ol hydrochloride
(1R,2S)-2-amino-1,2,3,4-tetrahydronaphthalen-1-ol
cis-2-fluorocyclopropylaminetosylate
Phenylpropanolamine-d5
(1S,2R)-2-BROMO-CYCLOPENTANOL
Methyl 2-bromo-6-(tert-butylamino)isonicotinate
tert-butyl N,N-bis(2-fluoroethyl)carbamate
tert-butyl 2-(3-acetyl-7-methyl-5-(2-methylpyrimidin-5-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl)acetate
tert-butyl 2-(3-acetyl-5-bromo-7-methyl-1H-pyrrolo[2,3-c]pyridin-1-yl)acetate
Methyl 5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazine-2-carboxylate
5-[2-(3-fluorophenyl)-1-pyrrolidinyl]-2-Pyrazinamine
Tert-butyl (5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazin-2-yl)carbamate
tert-Butyl 2-(6-bromo-3-iodo-1H-indazol-1-yl)acetate
2-[(2R)-2-(3-fluorophenyl)-1-pyrrolidinyl]-5-Pyrimidinamine
Methyl 5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrimidine-2-carboxylate

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