Procodazole

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Names

[ Name ]:
Procodazole

[Synonym ]:
3-(1H-benzo[d]imidazol-2-yl)propanoic acid
Procodazol
Procodazole
3-(1H-benzimidazol-2-yl)propanoic carboxylic acid
2-Benzimidazolepropionic acid
Propazole
2-benzimidazole propionic acid
1H-benzimidazole-2-propanoic acid
3-(1H-benzo-imidazol-2-yl)propionic acid
Procodazole [INN]
MFCD00041215
Propazol

Chemical & Physical Properties

[ Density]:
1.367 g/cm3

[ Boiling Point ]:
497.9ºC at 760 mmHg

[ Melting Point ]:
229-231 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₀H₁₀N₂O₂

[ Molecular Weight ]:
190.19900

[ Flash Point ]:
254.9ºC

[ Exact Mass ]:
190.07400

[ PSA ]:
65.98000

[ LogP ]:
1.58010

[ Vapour Pressure ]:
9.84E-11mmHg at 25°C

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UE7480000

CHEMICAL NAME :: Propionic acid, 2-(2-benzimidazolyl)-

CAS REGISTRY NUMBER :: 23249-97-0

BEILSTEIN REFERENCE NO. :: 0156920

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H10-N2-O2

MOLECULAR WEIGHT :: 190.22

WISWESSER LINE NOTATION :: T56 BM DNJ C2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 2,191,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 2,191,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 2,191,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 2,191,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 390 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 2,191,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 2,191,1977

Safety Information

[ Hazard Codes ]:
Xn: Harmful;Xi: Irritant;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S26-S37/39

[ WGK Germany ]:
3

[ RTECS ]:
UE7480000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-(methoxy(methyl)amino)-4-oxobutanoic acid
o-Phenylenediamine
Succinic acid
1H-Benzimidazole,2-(3-butenyl)-(9CI)
Succinic anhydride
benzene-o-diamine monohydrochloride
4-(2-aminoanilino)-4-oxobutanoic acid
Ethanol
benzene
1H-Pyrrolo[1,2-a]benzimidazol-1-one,2,3-dihydro-(6CI,8CI,9CI)

DownStream

3-(1H-BENZOIMIDAZOL-2-YL)-PROPIONIC ACID HYDRAZIDE
3-(1H-benzimidazol-2-yl)-N-hydroxypropanamide
1H-Pyrrolo[1,2-a]benzimidazol-1-one,2,3-dihydro-(6CI,8CI,9CI)
1H-Benzimidazole-2-propanamide(9CI)
3-(1-METHYL-1H-BENZOIMIDAZOL-2-YL)-PROPIONIC ACID
3-(1H-BENZOIMIDAZOL-2-YL)-ACRYLIC ACID
ethyl 3-(1H-benzoimidazol-2-yl)propanoate

Preparation

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%