Piperidine,2-[(4R)-2,2-diphenyl-1,3-dioxolan-4-yl]-, hydrochloride (1:1), (2R)-

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Names

[ CAS No. ]:
23257-58-1

[ Name ]:
Piperidine,2-[(4R)-2,2-diphenyl-1,3-dioxolan-4-yl]-, hydrochloride (1:1), (2R)-

[Synonym ]:
Levoxadrol
Levoxan
Cl-912c

Chemical & Physical Properties

[ Boiling Point ]:
468.4ºC at 760mmHg

[ Molecular Formula ]:
C20H24ClNO2

[ Molecular Weight ]:
345.86300

[ Flash Point ]:
237.1ºC

[ Exact Mass ]:
345.15000

[ PSA ]:
30.49000

[ LogP ]:
4.57600

[ Vapour Pressure ]:
3.6E-09mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM7640000
CHEMICAL NAME :
Piperidine, 2-(2,2-diphenyl-1,3-dioxolan-4-yl)-, hydrochloride, l-
CAS REGISTRY NUMBER :
23257-58-1
LAST UPDATED :
199012
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C20-H23-N-O2.Cl-H
MOLECULAR WEIGHT :
345.90
WISWESSER LINE NOTATION :
T6MTJ B- DT5O COTJ BR& BR &GH -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
310 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 153,105,1965
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
230 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 153,105,1965
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Behavioral - anticonvulsant Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 153,105,1965

Related Compounds

  • 2-({1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylbutanoyl]azetidin-3-yl}oxy)acetic acid
  • rac-2-{2-[(1R,3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentyl]acetamido}acetic acid
  • Benzeneacetic acid, 2-fluoro-5-(2-pyrrolidinyl)-
  • 3-[(3R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanamido]propanoic acid
  • 2-cyclobutyl-2-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopropyl]acetamido}acetic acid
  • 2-[2-cyclobutyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-N-propylacetamido]acetic acid
  • 1-{3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1-methyl-1H-pyrazole-5-amido}cyclobutane-1-carboxylic acid
  • 4-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methoxybutanamido]-1-methyl-1H-pyrazole-5-carboxylic acid
  • (3R)-3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-methylhex-4-enamido]hexanoic acid
  • (3R)-3-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopropyl]acetamido}hexanoic acid
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