6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

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Names

[ CAS No. ]:
2328-12-3

[ Name ]:
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

[Synonym ]:
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (1:1)
EINECS 251-223-7
6,7-dimethoxy-1,2,3,4-tetrahydroisochinoline hydrochloride
MFCD00012744
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride
1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinoline hydrochloride
Heliamine hydrochloride
6,7-Dimethoxy-1,2,3,4-tetrahydro-isoquinoline hydrochloride
Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride (1:1)
1,2,3,4-tetrahydro-6,7-dimethoxylsoquinoline hydrochloride
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline,chloride
1,2,3,4-tetrahydro-6,7-dimethoxy-,hydrochloride

Chemical & Physical Properties

[ Density]:
1.071g/cm3

[ Boiling Point ]:
314.9ºC at 760 mmHg

[ Melting Point ]:
260-265 °C(lit.)

[ Molecular Formula ]:
C11H16ClNO2

[ Molecular Weight ]:
229.703

[ Flash Point ]:
124.7ºC

[ Exact Mass ]:
229.086960

[ PSA ]:
30.49000

[ LogP ]:
2.48030

[ Vapour Pressure ]:
0.000451mmHg at 25°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NX5017980
CHEMICAL NAME :
Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride
CAS REGISTRY NUMBER :
2328-12-3
LAST UPDATED :
199009
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C11-H15-N-O2.Cl-H
MOLECULAR WEIGHT :
229.73

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
272 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 88,1197,1968
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 62,165,1938

Safety Information

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
3

[ RTECS ]:
NX5017980

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Formaldehyde
  • 3,4-Dimethoxyphenethylamine
  • dimethoxymethane
  • Hydrochloric acid

DownStream

  • 1,2,3,4-TETRAHYDRO-6,7-ISOQUINOLINEDIOL HYDROBROMIDE
  • Carbamic chloride
  • 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline
  • 6,7-Dimethoxyisoquinoline
  • Dehydroheliamine
  • 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[2-(4-nitrophenyl)ethyl]isoquinoline
  • 4-[2-(3,4-DIHYDRO-6,7-DIMETHOXY-2(1H)-ISOQUINOLINYL)ETHYL]-BENZENAMINE
  • Benzyl carbamate
  • N-Benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
  • Isoquinoline,1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%