(1S,2R)-2-Amino-1,2-diphenylethanol

Names

[ Name ]:
(1S,2R)-2-Amino-1,2-diphenylethanol

[Synonym ]:
(1S,2R)-2-Amino-1,2-diphenylethanol
(1S,2r)-(+)-2-Amino-1,2-Diphenylehanol
Benzeneethanol, β-amino-α-phenyl-, (αS,βR)-
MFCD00074960
(1S,2R)-(+)-2-Amino-1,2-diphenylethanol

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
374.3±37.0 °C at 760 mmHg

[ Melting Point ]:
142-144 °C(lit.)

[ Molecular Formula ]:
C₁₄H₁₅NO

[ Molecular Weight ]:
213.28

[ Flash Point ]:
180.2±26.5 °C

[ Exact Mass ]:
213.115356

[ PSA ]:
46.25000

[ LogP ]:
2.28

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.622

[ Storage condition ]:
2~8°C

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Benzoin oxime
(1R,2S)-1,2-diphenyl-2-triisopropylsilanyloxyethylamine
(SS)-(+)-N-(benzylidene)-p-toluenesulfinamide
(S)-2-(Triisopropylsyloxymethyl)phenyl p-tolylsulfoxide
[1R,2S,(S)S]-N-{1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-triisopropylsilanyloxyethyl}-p-toluenesulfinamide
2-amino-1,2-diphenyl-ethanol
(1R,2S)-1-phenyl-2-{(S)-2-(p-toluenesulfinyl)phenyl}-2-triisopropylsilanyloxyethylamine
[1R,2S,(S)S]-N-{2-hydroxy-1-phenyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}-p-toluenesulfinamide

DownStream

(4R,5S)-CIS-4,5-DIPHENYLOXAZOLIDIN-2-ONE
BENZYL (2S,3R)-(+)-6-OXO-2,3-DIPHENYL-4-MORPHOLINECARBOXYLATE
tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate
(1s,2r)-2-(isopropylamino)-1,2-diphenylethanol
ETHYL 2-(((1R,2S)-2-HYDROXY-1,2-DIPHENYLETHYL)AMINO)ACETATE

Preparation

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds.

Bioorg. Med. Chem. 17 , 3456-62, (2009)

We resolved 1,2-diphenylethylamine (DPEA) into its (S)- and (R)-enantiomer and used them as precursors for synthesis of (S)- and (R)-1-(1,2-diphenylethyl)piperidine, flexible homeomorphs of the NMDA c...

(1S,2R)-2-Amino-1,2-diphenylethanol
(1S,2R)-n-benzyl-2-amino-1,2-diphenylethanol
(1R,2R)-(-)-2-Amino-1,2-diphenylethanol
ETHYL 2-(((1R,2S)-2-HYDROXY-1,2-DIPHENYLETHYL)AMINO)ACETATE
cis-2-Amino-tetralol-(1)
(1s,2r)-2-(isopropylamino)-1,2-diphenylethanol
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
benzyl N-{2-ethynyl-7-oxaspiro[3.5]nonan-2-yl}carbamate
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
3-(1-Benzothiophen-2-yl)-1,1,1-trifluoropropan-2-one
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine