2-aminoindane HCl

Suppliers

Names

[ Name ]:
2-aminoindane HCl

[Synonym ]:
2-indanylaminehydrochloride
2-aminoindane HCl
1H-Inden-2-amine, 2,3-dihydro-, hydrochloride (9CI)
Indan-2-aminium chloride
2-INDANAMINE HCL
2,3-dihydro-1H-inden-2-amine hydrochloride (1:1)
2-Aminoindane hydrochloride
2-Indanamine hydrochloride
2-Indanamine hydrochloride (1:1)
Indan-2-amine hydrochloride (1:1)
MFCD00012549
Su-8629 hydrochloride
indan-2-ylamine,hydrochloride
2-Aminoindan HCL
EINECS 219-048-0
2,3-Dihydro-1H-inden-2-amine hydrochloride
2-AI (hydrochloride)
1H-Inden-2-amine, 2,3-dihydro-, hydrochloride (1:1)

Chemical & Physical Properties

[ Density]:
1.056g/cm3

[ Boiling Point ]:
226.2ºC at 760mmHg

[ Melting Point ]:
245-247 °C(lit.)

[ Molecular Formula ]:
C₉H₁₂ClN

[ Molecular Weight ]:
169.651

[ Flash Point ]:
96.8ºC

[ Exact Mass ]:
169.065826

[ PSA ]:
26.02000

[ LogP ]:
2.61480

[ Vapour Pressure ]:
0.0831mmHg at 25°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK4050000

CHEMICAL NAME :: 2-Indanamine, hydrochloride

CAS REGISTRY NUMBER :: 2338-18-3

LAST UPDATED :: 199606

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C9-H11-N.Cl-H

MOLECULAR WEIGHT :: 169.67

WISWESSER LINE NOTATION :: L56T&J CZ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 326 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - analgesia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 133,400,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Behavioral - analgesia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 133,400,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 158 mg/kg

TOXIC EFFECTS :: Behavioral - analgesia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 133,400,1961

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - analgesia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 133,400,1961 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 405 mg/kg/30D-I

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Gastrointestinal - nausea or vomiting

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 132,400,1961

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NK4050000

[ Packaging Group ]:
I; II; III

[ HS Code ]:
2921499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

N-(2,3-Dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide
N-(2,3-dihydro-1H-inden-2-yl)formamide
AVE-9488
ethyl N-(2,3-dihydro-1H-inden-2-yl)carbamate
5-Bromo-indan-2-ylamine
N-(2,3-Dihydro-1H-inden-2-yl)acetamide
N-(2,3-dihydro-1H-inden-2-yl)propanamide
2-Indanamine
methyl N-[(2R)-5-amino-2,3-dihydro-1H-inden-2-yl]carbamate
5-BROMO-2,3-DIHYDRO-1H-INDEN-2-AMINE HYDROCHLORIDE

Customs

[ HS Code ]: 2921499090

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Central cyanosis on a psychiatric unit treated at the Salford Royal Hospital.

Thorax 69(12) , 1157-8, (2014)

We describe a case of acquired methaemoglobinaemia due to frequent use of the 'legal high' known as 'Pink Panthers'. This contains 5,6-Methylenedioxy-2-aminoindane and 2-Aminoindane, both amphetamine ...

Oxygen-18 studies on the oxidative deamination mechanism of alicyclic primary amines in rabbit liver microsomes.

Arch. Biochem. Biophys. 215(2) , 433-43, (1982)

Assessment of a potential dopaminergic prodrug moiety in several ring systems.

J. Med. Chem. 29(10) , 2016-20, (1986)

The ortho hydroxy/methyl, hydroxy/hydroxymethyl, hydroxy/formyl, and hydroxy/carboxy substitution patterns, some of which confer dopaminergic agonist effects upon 2-aminotetralin ring systems, have be...