Thioproperazine dimesylate
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Names
[ CAS No. ]:
2347-80-0
[ Name ]:
Thioproperazine dimesylate
[Synonym ]:
10-[3-(4-methyl-piperazin-1-yl)-propyl]-10H-phenothiazine-2-sulfonic acid dimethylamide,bis-methanesulfonate
Mageptyl
thioproperazine dimethanosulphonate
Thioproperazine dimesylate
Thioperazine methanesulfate
thioproperazine mesylate
Thioproperazindimethansulfat
Majeptil
Thioproperazine dimesilate
Thioperazine dimethanesulfonate
Thioproperazine mesilate
Thioproperazine dimethanesulfonate
thioproperazine dimethansulfonate
Chemical & Physical Properties
[ Boiling Point ]:
612.2ºC at 760mmHg
[ Melting Point ]:
218-222ºC
[ Molecular Formula ]:
C24H38N4O8S4
[ Molecular Weight ]:
638.84100
[ Exact Mass ]:
638.15700
[ PSA ]:
206.28000
[ LogP ]:
5.36830
[ Vapour Pressure ]:
6.32E-15mmHg at 25°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SP5425000
- CHEMICAL NAME :
- Phenothiazine-2-sulfonamide, N,N-dimethyl-10-(3-(4-methyl-1-piperazinyl)propyl)-, dimethanesulfonate
- CAS REGISTRY NUMBER :
- 2347-80-0
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C22-H30-N4-O2-S2.2C-H4-O3-S
- MOLECULAR WEIGHT :
- 638.90
- WISWESSER LINE NOTATION :
- T C666 BN ISJ ESWN1&1 B3- AT6N DNTJ D1 &OSW1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 59 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 115 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 70 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 5 mg/kg
- REFERENCE :
- CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 9(5),14,1975
Safety Information
[ Hazard Codes ]:
Xn