CGP77675

[ Molecular Formula ]:
C₂₆H₂₉N₅O₂

[ Molecular Weight ]:
443.54100

[ Exact Mass ]:
443.23200

[ PSA ]:
89.43000

[ LogP ]:
4.19660

[ Appearance of Characters ]:
powder,white to beige

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: >10mg/mL

Click to get detail MSDS

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells.

PLoS ONE 4 , e4449, (2009)

Cilengitide is a high-affinity cyclic pentapeptdic alphaV integrin antagonist previously reported to suppress angiogenesis by inducing anoikis of endothelial cells adhering through alphaVbeta3/alphaVb...

Mechanisms involved in PGE2-induced transactivation of the epidermal growth factor receptor in MH1C1 hepatocarcinoma cells.

J. Exp. Clin. Cancer Res 31 , 72, (2013)

It is important to understand the mechanisms by which the cells integrate signals from different receptors. Several lines of evidence implicate epidermal growth factor (EGF) receptor (EGFR) in the pat...

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