Benfluorex hydrochloride

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Names

[ CAS No. ]:
23642-66-2

[ Name ]:
Benfluorex hydrochloride

Chemical & Physical Properties

[ Density]:
1.183g/cm3

[ Boiling Point ]:
420.5ºC at 760mmHg

[ Melting Point ]:
158-159?C

[ Molecular Formula ]:
C19H21ClF3NO2

[ Molecular Weight ]:
387.82400

[ Flash Point ]:
208.1ºC

[ Exact Mass ]:
387.12100

[ PSA ]:
38.33000

[ LogP ]:
5.27590

[ Vapour Pressure ]:
2.81E-07mmHg at 25°C

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KL8526000
CHEMICAL NAME :
Ethanol, 2-((1-methyl-2-(3-(trifluoromethyl)phenyl)ethyl)amino )-, benzoate (ester), hydrochloride
CAS REGISTRY NUMBER :
23642-66-2
LAST UPDATED :
199509
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C19-H20-F3-N-O2.Cl-H
MOLECULAR WEIGHT :
387.86

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
108 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 195,252,1972

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
KL8275000

Articles

[Benfluorex and valvular heart disease].

Presse Med. 40(11) , 1008-16, (2011)

Benfluorex is responsible of restrictive organic valvular regurgitations via one of its metabolites, the norfenfluramine. It has been withdrawn from the european market in June 2010. In France, about ...

[About the settlement of litigations concerning the harm caused by benfluorex (Mediator®)].

Presse Med. 42(4 Pt 1) , 411-8, (2013)

Since September 1st 2011, the National Bureau for Compensation of Medical Accidents represents a unique portal for out-of-court settlement of litigations concerning the harm caused by benfluorex. In D...

[Reform Act on safety of drug and health products in France: announcement effect, strengthening or upheaval?].

Therapie. 67(1) , 1-10, (2012)

In France, the Médiator(®) scandal and the trauma it has created, are the source of Law n° 2011-2012 of 29 December 2011 on strengthening safety of drug and health products, intended by the Ministry o...


More Articles

Related Compounds

  • benfluorex hydrochloride
  • Tyrocidine, hydrochloride
  • Triprolidine hydrochloride
  • Minoxidil hydrochloride
  • neomycin hydrochloride
  • dodecylamine hydrochloride
  • 2-[4-(5-Methyl-1,3-thiazol-2-yl)piperazin-1-yl]-4-(pyrrolidin-1-yl)pyrimidine
  • 4-[4-(5-Methyl-1,3-thiazol-2-yl)piperazin-1-yl]-6-(pyrrolidin-1-yl)pyrimidine
  • 4-[4-(5-Methyl-1,3-thiazol-2-yl)piperazin-1-yl]-2-(pyrrolidin-1-yl)pyrimidine
  • N-({4-fluoro-1-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl}methyl)oxolane-3-carboxamide
  • 1-(2-{4-[2-Methyl-6-(morpholin-4-yl)pyrimidin-4-yl]piperazin-1-yl}ethyl)pyrrolidin-2-one
  • 1-(Azepan-1-yl)-2-{3-[(pyrazin-2-yloxy)methyl]pyrrolidin-1-yl}ethan-1-one
  • 6-methoxy-N-[1-(3-methylbut-2-en-1-yl)piperidin-4-yl]pyrimidin-4-amine
  • 9-(2-methoxyethyl)-6-(3-methylpiperidin-1-yl)-9H-purine
  • 6-(4,4-difluoropiperidin-1-yl)-9-(2-methoxyethyl)-9H-purine
  • 4-(4-Benzylpiperazine-1-carbonyl)-6-(difluoromethyl)-2-methylpyrimidine
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