Benfluorex hydrochloride

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Names

[ CAS No. ]:
23642-66-2

[ Name ]:
Benfluorex hydrochloride

Chemical & Physical Properties

[ Density]:
1.183g/cm3

[ Boiling Point ]:
420.5ºC at 760mmHg

[ Melting Point ]:
158-159?C

[ Molecular Formula ]:
C19H21ClF3NO2

[ Molecular Weight ]:
387.82400

[ Flash Point ]:
208.1ºC

[ Exact Mass ]:
387.12100

[ PSA ]:
38.33000

[ LogP ]:
5.27590

[ Vapour Pressure ]:
2.81E-07mmHg at 25°C

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KL8526000
CHEMICAL NAME :
Ethanol, 2-((1-methyl-2-(3-(trifluoromethyl)phenyl)ethyl)amino )-, benzoate (ester), hydrochloride
CAS REGISTRY NUMBER :
23642-66-2
LAST UPDATED :
199509
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C19-H20-F3-N-O2.Cl-H
MOLECULAR WEIGHT :
387.86

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
108 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 195,252,1972

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
KL8275000

Articles

[Benfluorex and valvular heart disease].

Presse Med. 40(11) , 1008-16, (2011)

Benfluorex is responsible of restrictive organic valvular regurgitations via one of its metabolites, the norfenfluramine. It has been withdrawn from the european market in June 2010. In France, about ...

[About the settlement of litigations concerning the harm caused by benfluorex (Mediator®)].

Presse Med. 42(4 Pt 1) , 411-8, (2013)

Since September 1st 2011, the National Bureau for Compensation of Medical Accidents represents a unique portal for out-of-court settlement of litigations concerning the harm caused by benfluorex. In D...

[Reform Act on safety of drug and health products in France: announcement effect, strengthening or upheaval?].

Therapie. 67(1) , 1-10, (2012)

In France, the Médiator(®) scandal and the trauma it has created, are the source of Law n° 2011-2012 of 29 December 2011 on strengthening safety of drug and health products, intended by the Ministry o...


More Articles

Related Compounds

  • benfluorex hydrochloride
  • Tyrocidine, hydrochloride
  • Triprolidine hydrochloride
  • Minoxidil hydrochloride
  • neomycin hydrochloride
  • dodecylamine hydrochloride
  • 1-[(4-chloro-1H-pyrazol-1-yl)methyl]-3,5-dimethyl-1H-pyrazol-4-amine
  • N-(3-(Hydrazinecarbonyl)phenyl)acetamide
  • Ethyl 7-methyl-2-oxo-1,2-dihydropyrazolo[1,5-a]pyridine-6-carboxylate
  • 2-(1-(4-fluorobenzyl)-1H-1,2,4-triazol-3-yl)-4,5-dimethoxyisoindoline-1,3-dione
  • [7-(1-ethyl-5-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl][7-(trifluoromethyl)-6,7-dihydropyrazolo[1,5-a]pyrimidin-4(5H)-yl]methanone
  • 7-(((2-Chlorophenyl)amino)(phenyl)methyl)quinolin-8-ol
  • N-(3-cyano-4,5-dimethylthiophen-2-yl)-4-methyl-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide
  • N-[1-(1-ethyl-1H-pyrazol-3-yl)ethyl]-1-methyl-3-(trifluoromethyl)-1H-thieno[2,3-c]pyrazole-5-carboxamide
  • 5-Ethyl-N-(1-ethyl-3-methyl-1H-pyrazol-5-yl)-3-thiophenecarboxamide
  • 7-Methyl-5-[[4-(4-methyl-2-quinolinyl)-1-piperazinyl]carbonyl]pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
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