sodium,4-(dipropylsulfamoyl)benzoate

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Names

[ Name ]:
sodium,4-(dipropylsulfamoyl)benzoate

[Synonym ]:
p-(Dipropylsulfamoyl)benzoic acid,sodium salt
p-(Di-n-propylsulfamyl)benzoic acid,sodium salt
Benemid,sodium salt
p-(Dipropylsulfamyl)benzoic acid,sodium salt
sodium 4-(dipropylsulfamoyl)benzoate
BENZOIC ACID,p-(DIPROPYLSULFAMOYL)-,SODIUM SALT
Probenecid sodium
Probenecid sodium salt
Sodium probenecid

Chemical & Physical Properties

[ Boiling Point ]:
438ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₁₈NNaO₄S

[ Molecular Weight ]:
307.34100

[ Flash Point ]:
218.7ºC

[ Exact Mass ]:
307.08500

[ PSA ]:
85.89000

[ LogP ]:
1.94160

[ Vapour Pressure ]:
1.91E-08mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG9450000

CHEMICAL NAME :: Benzoic acid, p-(dipropylsulfamoyl)-, sodium salt

CAS REGISTRY NUMBER :: 23795-03-1

LAST UPDATED :: 199009

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C13-H18-N-O4-S.Na

MOLECULAR WEIGHT :: 307.37

WISWESSER LINE NOTATION :: QVR DSWN3&3 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 630 mg/kg/6W

TOXIC EFFECTS :: Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - changes primarily in glomeruli

REFERENCE :: ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS. Volume(issue)/page/year: 94,241,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1604 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - tetany Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 102,208,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 394 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - tetany Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 102,208,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 611 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - tetany Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 102,208,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1666 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - tetany Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 102,208,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1156 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - tetany Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 102,208,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 458 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - tetany Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 102,208,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - tetany Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 102,208,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 304 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - tetany Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 102,208,1951

Related Compounds

methyl 4-(dipropylsulfamoyl)benzoate
Sodium 4-(trifluoromethyl)benzoate
sodium-<4-benzyloxy benzoate>
sodium,4-(hexadecylamino)benzoate
Sodium; 4-isopropyl-benzoate
sodium 4-[(octadecylamino)carbonyl]benzoate
6-(2-Bromoethyl)-6a(2)-methyl-2,2a(2)-bipyridine
4-fluoro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid
Methyl5-(bromomethyl)oxazole-2-carboxylate
1-(4-Chloro-2-(difluoromethoxy)phenyl)hydrazine
1-Chloro-1-(4-(chloromethyl)-2-mercaptophenyl)propan-2-one
(1s)-1-(5-Chloro-2-methoxypyridin-4-yl)ethan-1-amine
3-(2-Bromo-5-cyanophenyl)propanoic acid
2,3-Dimethyl-4-fluorobenzenesulfonyl chloride
4-(Difluoromethoxy)-2,6-difluoropyridine
1-Chloro-1-(2-ethyl-3-mercaptophenyl)propan-2-one

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