Cinepazide

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Names

[ CAS No. ]:
23887-46-9

[ Name ]:
Cinepazide

[Synonym ]:
Piperazine,1-((1-pyrrolidinylcarbonyl)methyl)-4-(3,4,5-trimethoxycinnamoyl)
1-(2-oxo-2-pyrrolidin-1-yl-ethyl)-4-[3-(3,4,5-trimethoxy-phenyl)-acryloyl]-piperazine
2-Propen-1-one, 1-[4-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)-
1-((1-Pyrrolidinylcarbonyl)methyl)-4-(3,4,5-trimethoxycinnamoyl)piperazine
(2E)-1-{4-[2-Oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl}-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one
Cinepazida [INN-Spanish]
1-[2-Oxo-2-(1-pyrrolidinyl)ethyl]-4-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]piperazine
1-[4-[(3',4',5'-Trimethoxycinnamoyl)-1-piperazinyl]acetyl]pyrrolidine
Cinepazidum [INN-Latin]
1-(PYRROLIDIN-1-YLCARBONYLMETHYL)-4-(3,4,5-TRIMETHOXYCINNAMOYL)PIPERAZINE
Cinepazide
MFCD00868266
1-[(1-Pyrrolidinylcarbonyl)methyl]-4-(3,4,5-trimethoxycinnamoyl)piperazine
Piperazine, 1-(2-oxo-2-(1-pyrrolidinyl)ethyl)-4-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)-
Piperazine,1-(2-oxo-2-(1-pyrrolidinyl)ethyl)-4-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)
(2E)-1-{4-[2-Oxo-2-(pyrrolidin-1-yl)ethyl]piperazin-1-yl}-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
1-[4-[2-Oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl]-3-(3,4,5-trimethoxyphenyl)-2-propen-1-one
Piperazine, 1-((1-pyrrolidinylcarbonyl)methyl)-4-(3,4,5-trimethoxycinnamoyl)-
EINECS 245-928-9

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
637.8±55.0 °C at 760 mmHg

[ Melting Point ]:
170 - 175ºC

[ Molecular Formula ]:
C22H31N3O5

[ Molecular Weight ]:
417.499

[ Flash Point ]:
339.5±31.5 °C

[ Exact Mass ]:
417.226379

[ PSA ]:
71.55000

[ LogP ]:
1.64

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.575

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM2486800
CHEMICAL NAME :
Piperazine, 1-(2-oxo-2-(1-pyrrolidinyl)ethyl)-4-(1-oxo-3-(3,4,5-t rimethoxyphenyl)-2-pr openyl)-
CAS REGISTRY NUMBER :
23887-46-9
BEILSTEIN REFERENCE NO. :
0903854
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C22-H31-N3-O5
MOLECULAR WEIGHT :
417.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
44640 mg/kg/31D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,375,1979

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-(Pyrrolidinocarbonylmethyl)piperazine
  • (2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl chloride

DownStream

Related Compounds

  • cinepazide
  • Cinepazide
  • (Z)-Cinepazide
  • Cinepazide maleate
  • CINEPAZIDE MALEATE
  • Cinepazide N-Oxide
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 1-(5-Chloro-2-methoxy-4-pyridinyl)-4-piperidinol
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 3-Bromo-1-[(1-ethylpyrazol-3-yl)methyl]indazol-4-amine