Thioflavine T

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Names

[ CAS No. ]:
2390-54-7

[ Name ]:
Thioflavine T

[Synonym ]:
2-[4-(Dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium chloride
THIOFLAVINET,TG
EINECS 219-228-9
THIOFLAVINE TG
2-(4-(Dimethylamino)phenyl)-3,6-dimethylbenzo[d]thiazol-3-ium chloride
thioflavin T
MFCD00011944
Acronol Yellow T
SETOFLAVINE T
Benzothiazolium, 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-, chloride (1:1)
BASIC YELLOW 1
Setoflavin T
Thioflavine TCN
Thioflavine T
Benzothiazolium, 2-[4- (dimethylamino)phenyl]-3,6-dimethyl-, chloride

Chemical & Physical Properties

[ Melting Point ]:
212ºC

[ Molecular Formula ]:
C17H19ClN2S

[ Molecular Weight ]:
318.864

[ Exact Mass ]:
318.095734

[ PSA ]:
35.36000

[ LogP ]:
0.77120

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
32041300

Precursor & DownStream

Precursor

  • Methanol
  • 4-(6-Methyl-2-benzothiazolyl)benzeneamine
  • BTA-2
  • methyl iodide

DownStream

  • BTA-2

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity.

Molecular Neurodegeneration 10 , 8, (2015)

Aggregation and aggregation-mediated formation of toxic alpha synuclein (aSyn) species have been linked to the pathogenesis of sporadic and monogenic Parkinson's disease (PD). A novel H50Q mutation of...

β-cyclodextrin and curcumin, a potent cocktail for disaggregating and/or inhibiting amyloids: a case study with α-synuclein.

Biochemistry 53(25) , 4081-3, (2014)

Aggregation of α-synuclein has been implicated in Parkinson's disease (PD). While many compounds are known to inhibit α-synuclein aggregation, dissolution of aggregates into their constituent monomers...

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques.

Nat. Commun. 6 , 6176, (2015)

In Alzheimer's disease (AD), β-amyloid (Aβ) plaques are tightly enveloped by microglia processes, but the significance of this phenomenon is unknown. Here we show that microglia constitute a barrier w...


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Related Compounds

  • Thioflavine S
  • 4-(T-BUTOXY)PHENYLACETYLENE
  • 6-t-Butyl-2(1,2-dihydroxyethyl)-phenol
  • NEBMYCIN T
  • N-t-butoxycarbonyl-3-(2-pyrimidinyl)-1,2,5,6-tetrahydropyridine
  • N-t-BOC-4-(trifluoromethyl)phenylalanine
  • 2,5-Difluorobenzenesulfonic acid
  • 2-(3-((2,5-dimethylbenzyl)thio)-1H-indol-1-yl)-1-(4-methylpiperidin-1-yl)ethanone
  • 1-(4-methylpiperidin-1-yl)-2-(3-((4-(trifluoromethyl)benzyl)thio)-1H-indol-1-yl)ethanone
  • 6-{[3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}-3-phenyl-3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
  • 2-({1-[2-(2,6-dimethylmorpholin-4-yl)-2-oxoethyl]-1H-indol-3-yl}sulfanyl)acetamide
  • 2-((1-(2-(2,6-dimethylmorpholino)-2-oxoethyl)-1H-indol-3-yl)thio)-N-(2-fluorophenyl)acetamide
  • 6-{[3-(3-bromophenyl)-1,2,4-oxadiazol-5-yl]methyl}-3-(4-ethylphenyl)-3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
  • 3-{[4-(4-chlorophenyl)piperazin-1-yl]sulfonyl}-N-[(4-fluorophenyl)methyl]thiophene-2-carboxamide
  • 1-{[2-(3,5-dimethyl-1H-pyrazole-1-carbonyl)thiophen-3-yl]sulfonyl}-4-(2,5-dimethylphenyl)piperazine
  • N-(3-chlorophenyl)-2-((1-(2-(2,6-dimethylmorpholino)-2-oxoethyl)-1H-indol-3-yl)thio)acetamide