2-tert-Butyl-4-methylphenol

Suppliers

Names

[ Name ]:
2-tert-Butyl-4-methylphenol

[Synonym ]:
MONOBUTYL-P-CRESOL
4-Methyl-2,6-tert-butylphenol
2-tert-butyl-p-creso
2-tert-butyl-p-cresol
Phenol, (1,1-dimethylethyl)-4-methyl-
2-Terc.butyl-p-kresol
Phenol, 2- (1,1-dimethylethyl)-4-methyl-
MBPC
2-T-BUTYL-P-CRESOL
o-tert-Butyl-p-cresol
2-t-butyl-4-methylphenol
MTBP
MFCD00002381
RALOX 240
EINECS 219-314-6
Phenol, 2-(1,1-dimethylethyl)-4-methyl-
p-Butylcresol
4-Methyl-2-(2-methyl-2-propanyl)phenol
Lowinox MBPC
2-tert-butyl-4-methyl-1-hydroxybenzene
2-(tert-Butyl)-4-methylphenol
2-di-tert-butyl-4-methylphenol
2-tert-Butyl-4-methylphenol

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
237.0±0.0 °C at 760 mmHg

[ Melting Point ]:
50-52 °C(lit.)

[ Molecular Formula ]:
C₁₁H₁₆O

[ Molecular Weight ]:
164.244

[ Flash Point ]:
100.0±0.0 °C

[ Exact Mass ]:
164.120117

[ PSA ]:
20.23000

[ LogP ]:
3.63

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.513

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GO7000000

CHEMICAL NAME :: p-Cresol, 2-tert-butyl-

CAS REGISTRY NUMBER :: 2409-55-4

BEILSTEIN REFERENCE NO. :: 1817645

LAST UPDATED :: 199712

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C11-H16-O

MOLECULAR WEIGHT :: 164.27

WISWESSER LINE NOTATION :: QR D1 BX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - ulceration or bleeding from small intestine

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 144 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 940 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - tremor Behavioral - coma

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2100 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - tremor Behavioral - coma

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1180 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8100 mg/kg/30D-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - urine volume decreased Blood - pigmented or nucleated red blood cells

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/m3/15W-I

TOXIC EFFECTS :: Endocrine - other changes Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 84 gm/kg/20W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 336 gm/kg/8W (Continuous)

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 11,425,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2329 No. of Facilities: 736 (estimated) No. of Industries: 7 No. of Occupations: 8 No. of Employees: 12254 (estimated) No. of Female Employees: 786 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314-H411

[ Precautionary Statements ]:
P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R34;R51/53

[ Safety Phrases ]:
S26-S36/37/39-S45-S61-S29

[ RIDADR ]:
UN 2430 8/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
GO7000000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
29071900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

tert-Butyl Hydroperoxide
p-Cresol
tert-Butanol
Isobutylene
tert-butyl 4-methylphenyl ether
Methyl tert-butyl ether
2,4-xylenol
Butylated hydroxytoluene
Acetonitrile
o-cresol

DownStream

2,2'-Thiobis(6-tert-butyl-p-cresol)
2-tert-butyl-6-[(dimethylamino)methyl]-4-methylphenol
3-Tert-butyl-5-methylsalicylicacid
tri-(2-tert-butyl-4-methylphenyl)phosphite
2-Amino-4-methyl-6-tert-butylphenol
p-Cresol
4-tert-Butylphenol
2,4-Di-t-butylphenol
2-tert-butyl-4-methylphenol,methanesulfonic acid
1,2-Benzenediol,3-(1,1-dimethylethyl)-5-methyl-

Customs

[ HS Code ]: 2907199090

[ Summary ]:
2907199090 other monophenols VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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2-tert-butyl-4-methylphenol
2-tert-butyl-4-methylphenol,sulfurous acid
2-tert-butyl-4-methylphenol,phosphorous acid
2-tert-butyl-4-methylphenol,methanesulfonic acid
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2-tert-butyl-4-cyclohexyl-6-methylphenol
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