2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid

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Names

[ CAS No. ]:
2410-93-7

[ Name ]:
2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid

[Synonym ]:
N-[p-[[(2-AMino-4-hydroxy-6-pteridinyl)Methyl]MethylaMino]benzoyl]glutaMic Acid
N(10)-methylfolate
N-(10-methyl-pteroyl)-L-glutamic acid
N-[4-[[(2-AMino-3,4-dihydro-4-oxo-6-pteridinyl)Methyl]MethylaMino]benzoyl]-L-glutaMic Acid
Methotrexate impurity C
10-Methylpteroylglutamic acid
N10-methylfolic acid
N10-MethylpteroylglutaMic Acid
N-[p-[[(2-Amino-4-hydroxypteridin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid
N-[4-[[(2-Amino-4-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
1-methylfolic acid
N-(10-Methyl-pteroyl)-L-glutaminsaeure
10-methylpteroylglutamlic acid
N-[4-[Methyl(2-amino-4-hydroxypteridine-6-ylmethyl)amino]benzoyl]glutamic acid
2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid

Chemical & Physical Properties

[ Density]:
1.61g/cm3

[ Molecular Formula ]:
C20H21N7O6

[ Molecular Weight ]:
455.42400

[ Exact Mass ]:
455.15500

[ PSA ]:
204.75000

[ LogP ]:
1.36390

[ Index of Refraction ]:
1.732

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA0700000
CHEMICAL NAME :
Glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridyl)methyl)methylami no)benzoyl)-
CAS REGISTRY NUMBER :
2410-93-7
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H21-N7-O6
MOLECULAR WEIGHT :
455.48
WISWESSER LINE NOTATION :
T66 BN DN GN JNJ CZ EQ H1NVR D1Z&YVQ2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,688,1955

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methotrexate
  • N-(4-aminobenzoyl)-L-glutamic acid
  • N-(4-iodobenzoyl)-L-glutamic acid
  • N-[4-(Methylamino)benzoyl]-L-glutamic Acid
  • 6-Hydroxy-2,4,5-triaminopyrimidine
  • Propanal, 2,3-dibromo-

DownStream

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