Quinoxaline,1,4-dioxide

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Names

[ Name ]:
Quinoxaline,1,4-dioxide

[Synonym ]:
Grofas
quinoxaline N,N'-dioxide
Quindoxin
Quinoxaline dioxide
Celbar
BAY-Va 9391
benzopyrazine N,N'-dioxide
quinoxaline 1,4-bis-N-oxide
Quinoxaline di-N-oxide
USAF H-1
Chindoxin [Czech]
quinoxaline 1,4-di-N-oxide
Quinoxaline,1,4-dioxide
Bayo N-Ox

Chemical & Physical Properties

[ Density]:
1.3264 (rough estimate)

[ Boiling Point ]:
288.82 °C (rough estimate)

[ Melting Point ]:
216 °C(dec.)

[ Molecular Formula ]:
C₈H₆N₂O₂

[ Molecular Weight ]:
162.14500

[ Exact Mass ]:
162.04300

[ PSA ]:
50.92000

[ LogP ]:
1.69680

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VD2275000

CHEMICAL NAME :: Quinoxaline, 1,4-dioxide

CAS REGISTRY NUMBER :: 2423-66-7

LAST UPDATED :: 199512

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C8-H6-N2-O2

MOLECULAR WEIGHT :: 162.16

WISWESSER LINE NOTATION :: T66 BN ENJ BO EO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2970 mg/kg/12D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 1500 mg/kg/3D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5400 mg/kg/77W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 20 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 139,199,1984

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Quinoxaline
vinyl acetate
Benzofuroxan
ch3cho
2-QUINOXALINECARBOXYLICACID1,4-DIOXIDE
3-acetyl-1-hydroxy-4-oxo-quinoxaline-2-carboxylate
2-(dihydroxymethyl)quinoxaline 1,4-dioxide
Ethyl 4-phenyl-2,4-dioxobutyrate
Hydrogen peroxide
acetic acid

DownStream

(2-oxoquinoxalin-1-yl) acetate
1-hydroxy-2(1H)-quinoxalinone
DHQ
Quinoxaline
Quinoxaline, 1-oxide
Quinoxaline-2-carboxamide
2-(N-formylcarbamoyl)quinoxaline
2-chloro-1-oxidoquinoxalin-1-ium
2(1H)-Quinoxalinone
2(1H)-Quinoxalinone,4-oxide

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

2-(dihydroxymethyl)quinoxaline 1,4-dioxide
2-Dimethoxymethyl-quinoxaline 1,4-dioxide
2,3-bis(chloromethyl)quinoxaline 1,4-dioxide
2-acetoxymethyl-3-methyl-quinoxaline 1,4-dioxide
2,3-BIS(ACETOXYMETHYL)QUINOXALINE 1,4-DIOXIDE
2,3-BIS(HYDROXYMETHYL)QUINOXALINE-1,4-DIOXIDE
N-(m-tolyl)-2-(1-tosylpiperidin-2-yl)acetamide
N-(4-fluoro-3-(trifluoromethyl)phenyl)-2-(1-tosylpiperidin-2-yl)acetamide
N-(benzo[d][1,3]dioxol-5-ylmethyl)-2-(1-tosylpiperidin-2-yl)acetamide
N-(3-chloro-4-fluorophenyl)-2-(1-tosylpiperidin-2-yl)acetamide
N-(2,4-difluorophenyl)-2-(1-tosylpiperidin-2-yl)acetamide
N-(4-fluorophenyl)-2-(1-tosylpiperidin-2-yl)acetamide
N-(3-fluoro-4-methylphenyl)-2-(1-tosylpiperidin-2-yl)acetamide
N-(3-chloro-4-methoxyphenyl)-2-(1-tosylpiperidin-2-yl)acetamide
N-cycloheptyl-2-(1-tosylpiperidin-2-yl)acetamide
N-(4-bromo-2-methylphenyl)-2-(1-tosylpiperidin-2-yl)acetamide

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