carboquone

Names

[ CAS No. ]:
24279-91-2

[ Name ]:
carboquone

[Synonym ]:
Esquinon
Carbaziloquinone
Carbazilequinone
2,5-bis-aziridin-1-yl-3-(2-carbamoyloxy-1-methoxy-ethyl)-6-methyl-[1,4]benzoquinone
carboquone
Carboquonum [INN-Latin]
Carboquona [INN-Spanish]
Carbazilquinone
Carboquone [INN:JAN]
2,5-bis(1-aziridinyl)-3-(2-carbamoyloxy-1-methoxyethyl)-6-methyl-1,4-benzoquinone

Chemical & Physical Properties

[ Density]:
1.1990 (rough estimate)

[ Boiling Point ]:
460.09°C (rough estimate)

[ Melting Point ]:
202° (dec)

[ Molecular Formula ]:
C15H19N3O5

[ Molecular Weight ]:
321.32800

[ Exact Mass ]:
321.13200

[ PSA ]:
101.71000

[ Index of Refraction ]:
1.5600 (estimate)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DK3400000
CHEMICAL NAME :
p-Benzoquinone, 2,5-bis(1-aziridinyl)-3-(2-hydroxy-1-methoxyethyl)-6- methyl-, carbamate
CAS REGISTRY NUMBER :
24279-91-2
BEILSTEIN REFERENCE NO. :
1400765
LAST UPDATED :
199806
DATA ITEMS CITED :
19
MOLECULAR FORMULA :
C15-H19-N3-O5
MOLECULAR WEIGHT :
321.37
WISWESSER LINE NOTATION :
T3NTJ A- BL6V DVJ C1 FYO1&1OVZ E- AT3NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
27300 ug/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3070 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3990 ug/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3620 ug/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
28600 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3440 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4900 ug/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5430 ug/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
35 mg/kg/5W-C
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - changes in spleen weight Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
42 mg/kg/6W-C
TOXIC EFFECTS :
Endocrine - changes in spleen weight Endocrine - changes in thymus weight Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7 mg/kg/5W-C
TOXIC EFFECTS :
Endocrine - changes in spleen weight Endocrine - changes in thymus weight Related to Chronic Data - changes in uterine weight
TYPE OF TEST :
DNA damage

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
10 ug/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,3270,1984

Related Compounds

  • 2-[(3-acetamido-1H-1,2,4-triazol-5-yl)sulfanyl]butanoic acid
  • 3-(1-Acetylazetidin-3-yl)bicyclo[1.1.1]pentane-1-carboxylic acid
  • (2S)-2-(3-bromophenyl)-2-(2,2,2-trifluoroacetamido)acetic acid
  • 3-(1,1-Dioxo-1lambda6-thiolan-3-yl)-2-(2,2,2-trifluoroacetamido)propanoic acid
  • 3-(2-Methyl-5-nitrophenyl)prop-2-en-1-ol
  • 2-(N-cyclopentyl-2,2,2-trifluoroacetamido)benzoic acid
  • 2-{[(Benzyloxy)carbonyl]amino}-3-(3,5-dinitrophenyl)propanoic acid
  • 1-[4-[4-(5-fluoro-4-methyl-6-oxo-5H-pyrimidin-2-yl)piperazin-1-yl]sulfonylphenyl]pyrrolidine-2,5-dione
  • (3S,5S)-5-methoxypiperidin-3-ol hydrochloride
  • 2-Bromo-5-(piperidin-2-yl)pyridine, trifluoroacetic acid
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