carboquone

Names

[ Name ]:
carboquone

[Synonym ]:
Esquinon
Carbaziloquinone
Carbazilequinone
2,5-bis-aziridin-1-yl-3-(2-carbamoyloxy-1-methoxy-ethyl)-6-methyl-[1,4]benzoquinone
carboquone
Carboquonum [INN-Latin]
Carboquona [INN-Spanish]
Carbazilquinone
Carboquone [INN:JAN]
2,5-bis(1-aziridinyl)-3-(2-carbamoyloxy-1-methoxyethyl)-6-methyl-1,4-benzoquinone

Chemical & Physical Properties

[ Density]:
1.1990 (rough estimate)

[ Boiling Point ]:
460.09°C (rough estimate)

[ Melting Point ]:
202° (dec)

[ Molecular Formula ]:
C₁₅H₁₉N₃O₅

[ Molecular Weight ]:
321.32800

[ Exact Mass ]:
321.13200

[ PSA ]:
101.71000

[ Index of Refraction ]:
1.5600 (estimate)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DK3400000

CHEMICAL NAME :: p-Benzoquinone, 2,5-bis(1-aziridinyl)-3-(2-hydroxy-1-methoxyethyl)-6- methyl-, carbamate

CAS REGISTRY NUMBER :: 24279-91-2

BEILSTEIN REFERENCE NO. :: 1400765

LAST UPDATED :: 199806

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C15-H19-N3-O5

MOLECULAR WEIGHT :: 321.37

WISWESSER LINE NOTATION :: T3NTJ A- BL6V DVJ C1 FYO1&1OVZ E- AT3NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27300 ug/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3070 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3990 ug/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3620 ug/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28600 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3440 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4900 ug/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5430 ug/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 35 mg/kg/5W-C

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 42 mg/kg/6W-C

TOXIC EFFECTS :: Endocrine - changes in spleen weight Endocrine - changes in thymus weight Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 mg/kg/5W-C

TOXIC EFFECTS :: Endocrine - changes in spleen weight Endocrine - changes in thymus weight Related to Chronic Data - changes in uterine weight

TYPE OF TEST :: DNA damage

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 10 ug/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,3270,1984

Related Compounds

3-{[4-(1,2-Benzothiazol-3-yl)piperazin-1-yl]methyl}benzonitrile
2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]-N-benzylacetamide
4-{[1-(5-Methylthiophene-2-carbonyl)piperidin-4-yl]methoxy}pyridine-2-carboxamide
5-tert-butyl-N-(3-chloro-2-methylphenyl)-2-ethoxybenzene-1-sulfonamide
4-{[1-(1,3-dimethyl-1H-pyrazole-5-carbonyl)piperidin-4-yl]methoxy}pyridine-2-carboxamide
4-{[1-(2,5-Dimethylfuran-3-carbonyl)piperidin-4-yl]methoxy}pyridine-2-carboxamide
4-{[1-(1-Methyl-2-oxo-1,2-dihydropyridine-3-carbonyl)piperidin-4-yl]methoxy}pyridine-2-carboxamide
4-{[1-(5-Bromopyridine-3-carbonyl)piperidin-4-yl]methoxy}pyridine-2-carboxamide
4-{[1-(3-Fluoro-4-methylbenzoyl)piperidin-4-yl]methoxy}pyridine-2-carboxamide
4-{[1-(2,5-Dimethylbenzoyl)piperidin-4-yl]methoxy}pyridine-2-carboxamide

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