Valpromide
Suppliers
Names
[ CAS No. ]:
2430-27-5
[ Name ]:
Valpromide
[Synonym ]:
Depamide
2-Propylvaleramide
Valpromide
2,2-Di-n-propylacetamide
Pentanamide,2-propyl
EINECS 219-394-2
MFCD00051534
2-Ethylvaleramide
2-propylpentamide
2,2-BIS(TRIFLUOROMETHYL)PROPANOL
2-propylpentanamide
Dipropylacetamide
Valpramide
Chemical & Physical Properties
[ Density]:
0.885g/cm3
[ Boiling Point ]:
274.6ºC at 760mmHg
[ Melting Point ]:
123-125°C
[ Molecular Formula ]:
C8H17NO
[ Molecular Weight ]:
143.22700
[ Flash Point ]:
119.9ºC
[ Exact Mass ]:
143.13100
[ PSA ]:
43.09000
[ LogP ]:
2.38840
[ Vapour Pressure ]:
0.00535mmHg at 25°C
[ Index of Refraction ]:
1.44
[ Storage condition ]:
room temp
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YV5965500
- CHEMICAL NAME :
- Valeramide, 2-propyl-
- CAS REGISTRY NUMBER :
- 2430-27-5
- BEILSTEIN REFERENCE NO. :
- 1750444
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C8-H17-N-O
- MOLECULAR WEIGHT :
- 143.26
- WISWESSER LINE NOTATION :
- ZVY3&3
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 890 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GNAW "Pharmacodynamie de l'Acide Dipropylacetique (ou Propyl-2-Pentanoique) et de ses Amides," Carraz, G., Imprimerie Eymond, 1968 Volume(issue)/page/year: -,72,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 950 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GNAW "Pharmacodynamie de l'Acide Dipropylacetique (ou Propyl-2-Pentanoique) et de ses Amides," Carraz, G., Imprimerie Eymond, 1968 Volume(issue)/page/year: -,71,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 438 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 9,37,1988 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 600 mg/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,669,1986
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S22-S36/37
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
YV5965500
[ HS Code ]:
2924199090
Customs
[ HS Code ]: 2924199090
[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Int. J. Oncol. 47 , 343-52, (2015)
High-risk neuroblastoma remains one of the most important therapeutic challenges for pediatric oncologists. New agents or regimens are urgently needed to improve the treatment outcome of this fatal tu...
Birth Defects Res. B Dev. Reprod. Toxicol. 71(1) , 47-53, (2004)
The antiepileptic drug valproic acid (VPA) is well known to cause neural tube and skeletal defects in both humans and animals. The amidic VPA analogues valpromide (VPD) and valnoctamide (VCD) have muc...
Birth Defects Res. A Clin. Mol. Teratol. 70(11) , 870-9, (2004)
Valproic acid (VPA) is widely used to treat epilepsy and bipolar disorder and is also a potent teratogen, but its teratogenic mechanisms are unknown. We have attempted to describe a fundamental role o...