N,N-diethyl-2-phenylacetamide

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Names

[ Name ]:
N,N-diethyl-2-phenylacetamide

[Synonym ]:
N,N-diethylphenylacetic amide
EINECS 219-400-3
PhCH2CONEt2
N,N-diethyl-2-phenyl-acetamide
Phenyl-N,N-diethylacetamide
MFCD00192031
N,N-Diethylbenzeneacetamide
N,N-Diethylphenylacetamide
Phenyl-essigsaeure-diaethylamid

Chemical & Physical Properties

[ Density]:
0.992g/cm3

[ Boiling Point ]:
169ºC (18 torr)

[ Melting Point ]:
84-86 °C

[ Molecular Formula ]:
C₁₂H₁₇NO

[ Molecular Weight ]:
191.26900

[ Flash Point ]:
134.3ºC

[ Exact Mass ]:
191.13100

[ PSA ]:
20.31000

[ LogP ]:
2.09750

[ Vapour Pressure ]:
0.000691mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.522(lit.)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB7410000

CHEMICAL NAME :: Acetamide, N,N-diethyl-2-phenyl-

CAS REGISTRY NUMBER :: 2431-96-1

BEILSTEIN REFERENCE NO. :: 1867641

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C12-H17-N-O

MOLECULAR WEIGHT :: 191.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 825 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 31,755,1993

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1375 mg/m3/4H

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Blood - other changes

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 67,85,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1749 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IJSIDW Indian Journal of Pharmaceutical Sciences. (Kalina, Santa Cruz (East), Bombay 400 029, India) V.40(2)- 1978- Volume(issue)/page/year: 49,220,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Gastrointestinal - other changes

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 31,755,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 58,81,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 635 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Gastrointestinal - other changes

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 31,755,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3505 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 45,67,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 7100 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 58,81,1989 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/m3/6H/2W-I

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 67,85,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10500 mg/kg/21D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 58,81,1989

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S36

[ HS Code ]:
2924299090

Precursor & DownStream

Precursor

Diethylamine
(bromoethynyl)benzene
Phenylacetic acid
Diethylcarbamic chloride
Triethylamine
Phenylacetyl chloride
chlorozinc(1+),methanidylbenzene
carbon monoxide
Toluene
Methyl 2-phenylacetate

DownStream

Benzeneacetamide,N,N-diethyl-a-phenyl-
N,N-Diethylmandelamide
benzoic acid
7-Methoxy-3-phenyl-2H-chromen-2-one
3-phenyl-5,6-benzocoumarin
2H-1-Benzopyran-2-one,3-phenyl-

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

2-chloro-n,n-diethyl-2-phenylacetamide
N,N-diethyl-2-(2-methyl-2-(p-tolyl)hydrazono)-2-phenylacetamide
N,N-diethyl-2-[(6-methyl-2-nitro-3-pyridinyl)oxy]-2-phenylacetamide
N,N-diethyl-2-methylpropan-1-amine
N,N-diethyl-2-methylpent-2-en-4-yn-1-amine
N,N-Diethyl-2-(((3-beta,20R)-20-hydroxypregn-5-en-3-yl)oxy)-N-methylethanaminium 4-methylbenzenesulfonate
4-Bromo-2-(difluoromethyl)-5-methoxynicotinamide
4-Bromo-2-fluoro-6-hydroxybenzene-1-sulfonyl chloride
4-Amino-6-chloro-2-(difluoromethyl)nicotinonitrile
4-(Difluoromethyl)-6-iodopicolinamide
4-(Difluoromethyl)-6-methyl-5-(trifluoromethoxy)nicotinic acid
2-(4-Amino-2-fluoro-5-(trifluoromethoxy)pyridin-3-yl)acetic acid
2-(4-Bromo-6-(fluoromethyl)-5-(trifluoromethoxy)pyridin-3-yl)acetonitrile
4-Bromo-2-fluoro-6-(trifluoromethoxy)pyridine-3-sulfonamide
4-(Difluoromethyl)-6-methoxynicotinaldehyde
4-(Difluoromethyl)-2-methyl-6-(trifluoromethoxy)nicotinaldehyde

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