Apamin
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Names
[ CAS No. ]:
24345-16-2
[ Name ]:
Apamin
[Synonym ]:
apamine
MFCD00167944
N-{[(1R,4S,7S,13S,16S,19S,22S,25S,28R,31S,34S,37S,40R,47S,50R)-50-Amino-4-(4-aminobutyl)-47-(2-amino-2-oxoethyl)-34,37-bis(3-carbamimidamidopropyl)-16-(2-carboxyethyl)-19-(1-hydroxyethyl)-25-isobut yl-7,22,31-trimethyl-2,5,8,14,17,20,23,26,29,32,35,38,46,49-tetradecaoxo-42,43,52,53-tetrathia-3,6,9,15,18,21,24,27,30,33,36,39,45,48-tetradecaazatricyclo[26.16.10.0]tetrapentacont-40-yl]carbony ;l}-L-glutaminyl-L-glutaminyl-L-histidinamide
Apamin
APAMIN,BEE VENOM
APAMIN FROM BEE VENOM
CNCKAPETALCARRCQQH-NH2
M.W. 2027.34 C79H131N31O24S4
APAMIN FROM HONEY BEE VENOM
EINECS 246-182-7
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Molecular Formula ]:
C79H131N31O24S4
[ Molecular Weight ]:
2027.339
[ Exact Mass ]:
2025.886597
[ PSA ]:
1021.52000
[ LogP ]:
-14.24
[ Index of Refraction ]:
1.724
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CD6899900
- CHEMICAL NAME :
- Apamin
- CAS REGISTRY NUMBER :
- 24345-16-2
- LAST UPDATED :
- 198708
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C79-H131-N31-O24-S4
- MOLECULAR WEIGHT :
- 2027.65
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 22,308,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2900 ug/kg
- TOXIC EFFECTS :
- Behavioral - ataxia
- REFERENCE :
- EJBCAI European Journal of Biochemistry. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1967- Volume(issue)/page/year: 56,35,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement Behavioral - changes in motor activity (specific assay)
- REFERENCE :
- NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972- Volume(issue)/page/year: 300,189,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intracerebral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1800 ng/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 22,308,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,157,1982
Safety Information
[ Symbol ]:
GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H334
[ Precautionary Statements ]:
P261-P342 + P311
[ Hazard Codes ]:
Xn
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
UN 2811
[ WGK Germany ]:
3
[ RTECS ]:
CD6899900
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
Articles
Am. J. Physiol. Heart Circ. Physiol. 307(8) , H1093-102, (2014)
Impaired endothelial function, which is dysregulated in diabetes, also precedes hypertension. We hypothesized that in Type 2 diabetes, the impaired endothelium-dependent relaxation is due to a loss of...
Br. J. Pharmacol. 171(15) , 3633-50, (2014)
Subtypes of the hyperpolarization-activated cyclic nucleotide-gated (HCN) family of cation channels are widely expressed on nerves and smooth muscle cells in many organ systems, where they serve to re...
Br. J. Pharmacol. 172 , 3043-57, (2015)
Lysophosphatidylinositol (LPI), a lipid signalling molecule, activates GPR55 and elevates intracellular Ca(2+). Here, we examine the actions of LPI in the rat resistance mesenteric artery and Ca(2+) r...