leupeptin

Suppliers

Names

[ Name ]:
leupeptin

[Synonym ]:
acetyl-Leu-Leu-Arg-al
2-Methyl-5-oxotetrahydro-2-furanyl acetate
Acetyllaevulinsaeure
5-acetoxy-5-methyl-dihydro-furan-2-one
Ac-Leu-Leu-Arg-H
N-acetyl-Leu-Leu-argininal

Chemical & Physical Properties

[ Density]:
1.21g/cm3

[ Molecular Formula ]:
C₂₀H₃₈N₆O₄

[ Molecular Weight ]:
426.55400

[ Exact Mass ]:
426.29500

[ PSA ]:
166.27000

[ LogP ]:
2.37870

[ Index of Refraction ]:
1.557

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YV4205000

CHEMICAL NAME :: Valeramide, 2-(2-acetamido-4-methylvaleramido)-N-(1-formyl-4-guan idinobutyl)-4-methyl-

CAS REGISTRY NUMBER :: 24365-47-7

LAST UPDATED :: 198510

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C20-H38-N6-O4

MOLECULAR WEIGHT :: 426.64

WISWESSER LINE NOTATION :: MUYZM3YVHMVY1Y1&1&MVYMV1&1Y1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 720 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes

REFERENCE :: JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes

REFERENCE :: JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes

REFERENCE :: JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 740 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes

REFERENCE :: JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 540 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes

REFERENCE :: JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 74 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes

REFERENCE :: JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 3,9,1977

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(2S)-2-acetamido-N-((2S)-1-((1,1-dibutoxy-5-guanidinopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methylpentanamide
Z-Leu-OH
L-leucine
H-L-[U-14C]-Leu-L-Leu-L-Argal dibutylacetal

DownStream

Related Compounds

Leupeptin
Leupeptin
leupeptin
Leupeptin Pr-LL
Leupeptin hydrochloride
Leupeptin trifluoroacetate salt
(2E)-2-[(3-methylphenyl)methylidene]butanoic acid
2-(3,5-Dimethylphenoxy)-1,3-dimethylbenzene
Methyl I(2)-amino-4-(methoxycarbonyl)benzenepropanoate
N1-cyclopentyl-N2-(3-(4-(dimethylamino)phenyl)propyl)oxalamide
N-(4-(dimethylamino)phenethyl)-4-ethoxy-3-methylbenzenesulfonamide
N-(4-(N-(4-(dimethylamino)phenethyl)sulfamoyl)-3-methylphenyl)acetamide
N-(4-(N-(4-(dimethylamino)phenethyl)sulfamoyl)-3-methylphenyl)propionamide
N-(4-(dimethylamino)phenethyl)-4-methoxy-2-methylbenzenesulfonamide
3-chloro-N-(4-(dimethylamino)phenethyl)-4-methoxybenzenesulfonamide
5-chloro-N-(4-(dimethylamino)phenethyl)-2-methoxybenzenesulfonamide

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