Adenylthiomethylpentose

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Names

[ CAS No. ]:
2457-80-9

[ Name ]:
Adenylthiomethylpentose

[Synonym ]:
5-Methylthioadenosine
1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-β-D-Ribofuranose
β-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-
Vitamin L2
5'-S-Methylthioadenosine
(2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol
5'-S-Methyl-5'-thioadenosine
7-[Tetrahydro-3,4-dihydroxy-5-(methylmeracptomrthyl)-2-futyl]adenine
Adenosine, 5'-S-methyl-5'-thio-
5'-Deoxy-5'-(methylthio)adenosine
MFCD00010533
MTA,Methylthioadenosine
5'-Deoxy-5'-Methylthioadenosine
Adenylthiomethylpentose
(2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-3,4-diol

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
642.7±65.0 °C at 760 mmHg

[ Melting Point ]:
210-213ºC (dec.)

[ Molecular Formula ]:
C11H15N5O3S

[ Molecular Weight ]:
297.333

[ Flash Point ]:
342.5±34.3 °C

[ Exact Mass ]:
297.089569

[ PSA ]:
144.61000

[ LogP ]:
0.67

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.843

[ Storage condition ]:
−20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU7410000
CHEMICAL NAME :
Adenosine, 5'-S-methyl-5'-thio-
CAS REGISTRY NUMBER :
2457-80-9
BEILSTEIN REFERENCE NO. :
0042420
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C11-H15-N5-O3-S
MOLECULAR WEIGHT :
297.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
100 umol/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,653,1987

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AU7410000

[ HS Code ]:
2934999090

Precursor & DownStream

Precursor

  • Methyl mercaptan
  • 5'-Chloro-5'-deoxyadenosine
  • L-Methionine
  • Adenosine triphosphate
  • Sodium thiomethoxide
  • Adenosine
  • 5'-chloro-5'-deoxy-2',3'-O-sulfinyladenosine
  • methylthioadenosine sulfoxide
  • (((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(3-(2-hydroxyphenyl)-3-methylbutyl)(methyl)sulfonium
  • Dimethyl disulfide

DownStream

  • 5'-Deoxyadenosine
  • (2R,3S,4S)-2,3,4-trihydroxy-5-methylsulfanyl-pentanal
  • Adenine
  • 5'-deoxy-5'-((monofluoromethyl)thio)adenosine

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

  • 2-(5-Bromopyrimidin-2-yl)butanedioic acid
  • 1-(2-Methylcyclopropyl)cyclopropane-1-carboxylic acid
  • 4-(3-Ethylthiophen-2-yl)but-3-en-2-one
  • [2-(2,6-Dimethoxy-4-methylphenyl)propan-2-yl](methyl)amine
  • 3-(3-aminoprop-1-en-2-yl)-N,N-dimethylpyridin-2-amine
  • (1S)-2-amino-1-(3-ethylphenyl)ethan-1-ol
  • 3-Cycloheptylpentanedioic acid
  • Methyl 4-amino-4-cycloheptylbutanoate
  • (1R)-3-amino-1-(4,5-difluoro-2-nitrophenyl)propan-1-ol
  • tert-butyl N-[2-amino-1-(2-bromo-5-methylphenyl)ethyl]carbamate