Monoethyl fumarate

Suppliers

Names

[ Name ]:
Monoethyl fumarate

[Synonym ]:
Ethyl fumaric acid
2-Butenedioic acid, monoethyl ester, (2E)-
ETHYL ACID FUMARATE
Fumaric acid monoethyl ester
Monoethyl FuMerate
Ethyl fumarate
mono-Ethyl Fumarate
(2E)-4-Ethoxy-4-oxo-2-butenoic acid
RARECHEM AL BE 1505
Ethyl Hydrogen Fumarate
FuMaric Acid Ethyl Ester
Ethylfumarat
(2E)-4-ethoxy-4-oxobut-2-enoic acid
EINECS 219-544-7
Monoethyl FuMarate
monoethyl fumaric acid
MFCD00002699
(E)-4-Ethoxy-4-oxobut-2-enoic acid
ETHYL FUMARATE MONOESTER
Quetiapine Impurity 33

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
147 ºC (16 mmHg)

[ Melting Point ]:
64-69 ºC

[ Molecular Formula ]:
C₆H₈O₄

[ Molecular Weight ]:
144.125

[ Flash Point ]:
109.6±16.1 °C

[ Exact Mass ]:
144.042252

[ PSA ]:
63.60000

[ LogP ]:
0.29

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.469

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Monoethyl fumarate
EDA
ethyl i-propenyldiazoacetate
Maleic anhydride
Ethyl glyoxylate
Diethylphosphonoacetic acid
Diethyl fumarate
ethyl acetate
Maleic acid
Ethanol

DownStream

Maleic anhydride
(E)-Ethyl 4-oxobut-2-enoate
4-Ethoxy-4-oxobutanoic acid
3,7,10-trimethyl-(1H,3H,7H,10H)-pyrimido[5-4-g]pteridine-2,4,6,8-tetrone
Monoethyl fumarate
4-Oxoheptanoic acid ethyl ester
ethyl 4-(2-iodoanilino)-4-oxobut-2-enoate
ethyl 4-oxo-4-(2-oxo-1,3-oxazolidin-3-yl)but-2-enoate
Ethylfumaroylchloride
Ethyl succinyl chloride

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A).

Bioorg. Med. Chem. Lett. 21 , 2736-9, (2011)

Nicotinic acid (niacin) has been used for decades as an antidyslipidemic drug in man. Its main target is the hydroxy-carboxylic acid receptor HCA2 (GPR109A), a G protein-coupled receptor. Other acids ...

Fumarate analogs act as allosteric inhibitors of the human mitochondrial NAD(P)+-dependent malic enzyme.

PLoS ONE 9(6) , e98385, (2014)

Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by the four-carbon trans dicarboxylic acid, fumarate. Previous studies have suggested that the dicarboxylic...

The use of differential transverse relaxation to detect mobile species in solids.

Solid State Nucl. Magn. Reson. 6(1) , 63-71, (1996)

Delayed acquisition of the proton NMR in selected organic molecular solids (L-alanine, durene, ethyl fumarate, and p-hydroxybenzoic acid) is shown to allow the observation of mobile species in the pre...