Monoethyl fumarate

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Names

[ CAS No. ]:
2459-05-4

[ Name ]:
Monoethyl fumarate

[Synonym ]:
Ethyl fumaric acid
2-Butenedioic acid, monoethyl ester, (2E)-
ETHYL ACID FUMARATE
Fumaric acid monoethyl ester
Monoethyl FuMerate
Ethyl fumarate
mono-Ethyl Fumarate
(2E)-4-Ethoxy-4-oxo-2-butenoic acid
RARECHEM AL BE 1505
Ethyl Hydrogen Fumarate
FuMaric Acid Ethyl Ester
Ethylfumarat
(2E)-4-ethoxy-4-oxobut-2-enoic acid
EINECS 219-544-7
Monoethyl FuMarate
monoethyl fumaric acid
MFCD00002699
(E)-4-Ethoxy-4-oxobut-2-enoic acid
ETHYL FUMARATE MONOESTER
Quetiapine Impurity 33

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
147 ºC (16 mmHg)

[ Melting Point ]:
64-69 ºC

[ Molecular Formula ]:
C6H8O4

[ Molecular Weight ]:
144.125

[ Flash Point ]:
109.6±16.1 °C

[ Exact Mass ]:
144.042252

[ PSA ]:
63.60000

[ LogP ]:
0.29

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.469

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Monoethyl fumarate
  • EDA
  • ethyl i-propenyldiazoacetate
  • Maleic anhydride
  • Ethyl glyoxylate
  • Diethylphosphonoacetic acid
  • Diethyl fumarate
  • ethyl acetate
  • Maleic acid
  • Ethanol

DownStream

  • Maleic anhydride
  • (E)-Ethyl 4-oxobut-2-enoate
  • 4-Ethoxy-4-oxobutanoic acid
  • 3,7,10-trimethyl-(1H,3H,7H,10H)-pyrimido[5-4-g]pteridine-2,4,6,8-tetrone
  • Monoethyl fumarate
  • 4-Oxoheptanoic acid ethyl ester
  • ethyl 4-(2-iodoanilino)-4-oxobut-2-enoate
  • ethyl 4-oxo-4-(2-oxo-1,3-oxazolidin-3-yl)but-2-enoate
  • Ethylfumaroylchloride
  • Ethyl succinyl chloride

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A).

Bioorg. Med. Chem. Lett. 21 , 2736-9, (2011)

Nicotinic acid (niacin) has been used for decades as an antidyslipidemic drug in man. Its main target is the hydroxy-carboxylic acid receptor HCA2 (GPR109A), a G protein-coupled receptor. Other acids ...

Fumarate analogs act as allosteric inhibitors of the human mitochondrial NAD(P)+-dependent malic enzyme.

PLoS ONE 9(6) , e98385, (2014)

Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by the four-carbon trans dicarboxylic acid, fumarate. Previous studies have suggested that the dicarboxylic...

The use of differential transverse relaxation to detect mobile species in solids.

Solid State Nucl. Magn. Reson. 6(1) , 63-71, (1996)

Delayed acquisition of the proton NMR in selected organic molecular solids (L-alanine, durene, ethyl fumarate, and p-hydroxybenzoic acid) is shown to allow the observation of mobile species in the pre...


More Articles

Related Compounds

  • Monoethyl fumarate
  • Monoethyl fumarate sodium salt
  • Monoethyl FuMarate CalciuM Salt
  • monoethyl fumarate potassium salt
  • Monoethyl Dodecanedioate
  • Monoethyl phthalate
  • N-[2-(1-ethyl-1,2,3,4-tetrahydroquinolin-6-yl)ethyl]-N'-[(4-methylphenyl)methyl]ethanediamide
  • N1-(3,4-difluorophenyl)-N2-(2-(1-ethyl-1,2,3,4-tetrahydroquinolin-6-yl)ethyl)oxalamide
  • N1-(2-(1-ethyl-1,2,3,4-tetrahydroquinolin-6-yl)ethyl)-N2-(4-ethylphenyl)oxalamide
  • Methyl (R)-4-((5R,7R,8R,9S,10S,13R,14S,17R)-7-(methoxymethoxy)-10,13-dimethyl-3-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
  • 4-Chloro-8-methylcoumarin
  • 3-Iodopyrazine-2-carbaldehyde
  • 5-chloro-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyridine
  • 3-(4-bromo-2-fluorophenyl)-N-butyl-2-cyanoprop-2-enamide
  • 10H-Phenothiazine-10-acetic acid, 2-(aminothioxomethyl)hydrazide
  • 2-Carbamoylpropanoic acid ethyl ester
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