1-Piperazineaceticacid, 4-methyl-, 2-[(5-nitro-2-furanyl)methylene]hydrazide

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Names

[ Name ]:
1-Piperazineaceticacid, 4-methyl-, 2-[(5-nitro-2-furanyl)methylene]hydrazide

[Synonym ]:
Nifurpipone
UNII-G7274CK635
5-Nitro-2-furaldehyde 4-methylpiperazinoacethydrazone
5-Nitro-2-furaldehyde N'-methylpiperazinoacethydrazone
Nifurpiponum [INN-Latin]
Nifurpipone [INN]
5-Nitro-furfural-<(4-methyl-piperazino)-acetylhydrazon>
(4-methyl-piperazin-1-yl)-acetic acid (5-nitro-furan-2-ylmethylene)-hydrazide
Nifurpipona [INN-Spanish]
Rec 15 0122

Chemical & Physical Properties

[ Density]:
1.41g/cm3

[ Molecular Formula ]:
C₁₂H₁₇N₅O₄

[ Molecular Weight ]:
295.29400

[ Exact Mass ]:
295.12800

[ PSA ]:
106.90000

[ LogP ]:
0.67520

[ Index of Refraction ]:
1.635

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TK7906700

CHEMICAL NAME :: 1-Piperazineacetic acid, 4-methyl-, (5-nitrofurfurylidene)hydrazide

CAS REGISTRY NUMBER :: 24632-47-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C12-H17-N5-O4

MOLECULAR WEIGHT :: 295.34

WISWESSER LINE NOTATION :: T6N DNTJ A1 D1VMNU1- BT5OJ ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 990 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 114,73,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 212 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 114,73,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 880 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 114,73,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 315 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,633,1971

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

Benzonitrile, 4-[(3-aminophenyl)methyl]-
Methyl 2-(dimethyl-1,3-thiazol-5-yl)propanoate
1-Amino-3-cyclopropoxy-4-methylcyclohexane-1-carboxylic acid
Ethyl 1-amino-3-hydroxy-4-methylcyclohexane-1-carboxylate
3-(4-chloro-5-methyl-1H-pyrazol-1-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
3-(3-Cyano-5-fluorophenyl)-2,2-difluoropropanoic acid
3-(4-Bromo-1,2-thiazol-5-yl)-4-methylcyclohexan-1-one
4-Ethyl-3-[(thiophen-2-yl)methyl]cyclohexan-1-one
8-bromo-N-ethyl-N-propylquinazolin-2-amine
2-{[2-(Ethylsulfanyl)ethyl]amino}quinazoline-8-carboxylic acid

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