Dihydroergocristine mesylate
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Names
[ CAS No. ]:
24730-10-7
[ Name ]:
Dihydroergocristine mesylate
[Synonym ]:
dihydroergocristine methanesulphonate
DIHYDROERGOCRYSTINE METHANESULFONATE SALT
dihydroergocristine methane sulfonate
DIHYDROERGOCRISTINE METHANESULFONATE ERG OT ALKALOID,VASOC
Dihydroergocristine mesilate
9,10-DihydroergocristineMethanesulfonate
EINECS 246-434-6
dihydroergocristine methanesulfonate salt
Dihydroergocristine mesylate,(5'α,10α)-9,10-Dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-ergotaman-3',6',18-trionemesylate
PACAP 1-38
MFCD00153792
dihydroergocristinmesilat
DIHYDROERGOCRISTINE MESYLATE
dihydroergocristine
Chemical & Physical Properties
[ Boiling Point ]:
899.3ºC at 760 mmHg
[ Molecular Formula ]:
C36H45N5O8S
[ Molecular Weight ]:
707.83600
[ Flash Point ]:
497.7ºC
[ Exact Mass ]:
707.29900
[ PSA ]:
180.96000
[ LogP ]:
3.50660
[ Vapour Pressure ]:
8.49E-35mmHg at 25°C
[ Storage condition ]:
Store at RT
[ Water Solubility ]:
H2O: 10 mg/mL
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KE7600000
- CHEMICAL NAME :
- Ergotamane-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(pheny lmethyl)-, (5'-alpha,10-alpha)-, monomethanesulfonate (salt)
- CAS REGISTRY NUMBER :
- 24730-10-7
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C35-H41-N5-O5.C-H4-O3-S
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2643 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,1381,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 585 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,1381,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 91 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,1381,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2500 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,1381,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,1381,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 70 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4176182
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >1250 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - excitement Gastrointestinal - nausea or vomiting
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,1381,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >50 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - excitement Gastrointestinal - nausea or vomiting
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,1381,1992
Safety Information
[ RIDADR ]:
UN 1544 6
[ WGK Germany ]:
2
[ RTECS ]:
KE7600000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
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