Progesterone, 6.α.-chloro-17-hydroxy-, acetate

Names

[ CAS No. ]:
2477-73-8

[ Name ]:
Progesterone, 6.α.-chloro-17-hydroxy-, acetate

[Synonym ]:
17-Acetoxy-9a-chloropregan-4-ene-3,20-dione
6a-chloro-17-acetoxyprogesterone

Chemical & Physical Properties

[ Density]:
1.21g/cm3

[ Boiling Point ]:
519.3ºC at 760 mmHg

[ Molecular Formula ]:
C23H31ClO4

[ Molecular Weight ]:
406.94300

[ Exact Mass ]:
406.19100

[ PSA ]:
60.44000

[ LogP ]:
4.62650

[ Vapour Pressure ]:
6.95E-11mmHg at 25°C

[ Index of Refraction ]:
1.549

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU5010390
CHEMICAL NAME :
Pregn-4-ene-3,20-dione, 6-alpha-chloro-17-hydroxy-, acetate
CAS REGISTRY NUMBER :
2477-73-8
LAST UPDATED :
198910
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C23-H31-Cl-O4
MOLECULAR WEIGHT :
406.99

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
80 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press, 1965 Volume(issue)/page/year: -,57,1965

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 6β-Chlor-17α-hydroxyprogesteron-17-acetat
  • 3-Ethoxy-17-hydroxypregna-3,5-dien-20-one 17-acetate

DownStream

  • Chlormadinone Acetate

Related Compounds

  • Progesterone, 6.alpha.-fluoro-17-hydroxy-, acetate
  • [2-(4-chloro-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,4,5,6,7,8,9,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] acetate
  • (16α)-21-Chloro-17-hydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione
  • CLOMEGESTONE
  • Pregna-1,4-diene-3,11,20-trione,21-(acetyloxy)-6-chloro-17-hydroxy-, (6a)- (9CI)
  • Medroxyprogesterone 17-acetate