aluminum clofibrate

Names

[ Name ]:
aluminum clofibrate

[Synonym ]:
Aluminum hydroxide 2-(4-chlorophenoxy)-2-methylpropanoate (1:1:2)
Alfibrate
Aluminium hydroxide 2-(4-chlorophenoxy)-2-methylpropanoate (1:1:2)
Aluminum, bis[2-(4-chlorophenoxy)-2-methylpropanoato-κO]hydroxy-
Bis(2-(4-chlorophenoxy-kO)-2-methylpropanoateo-kO)hydroxyaluminum

Chemical & Physical Properties

[ Boiling Point ]:
324.1ºC at 760mmHg

[ Melting Point ]:
120-123ºC

[ Molecular Formula ]:
C₂₀H₂₄AlCl₂O₇

[ Molecular Weight ]:
471.264

[ Flash Point ]:
149.8ºC

[ Exact Mass ]:
470.047974

[ PSA ]:
121.78000

[ LogP ]:
2.65530

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BD0348000

CHEMICAL NAME :: Aluminum, bis(2-(4-chlorophenoxy-kappaO)-2-methylpropanoateo-ka ppaO)hydroxy-

CAS REGISTRY NUMBER :: 24818-79-9

LAST UPDATED :: 199803

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C20-H21-Al-Cl2-O7

MOLECULAR WEIGHT :: 471.29

WISWESSER LINE NOTATION :: OVX1&1&OR DG 2 &.AL-Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,237,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 23,281,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,237,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,237,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,237,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,237,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24 gm/kg/12D-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Related to Chronic Data - death

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 5,749,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24 gm/kg/12D-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 5,749,1971 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6 gm/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 5,749,1971

Safety Information

[ Safety Phrases ]:
S24/25

Related Compounds

Aluminum, benzoate iso-Pr alc. stearate complexes
aluminum;potassium;oxygen(2-);trihydrate
Aluminum,tris[(9Z)-9-octadecenoato-kO]-m-oxo(2-propanolato)di- (9CI)
aluminum phthalocyanine hydroxide
aluminum,carbonate,dihydroxide
aluminum,2-ethylhexanoate,benzoate
(2R)-2-{[1-(chloromethyl)cyclopropyl]methyl}oxolane
2-(3-Chloropropyl)-1lambda6-thiane-1,1-dione
4-(Bromomethyl)-1-chloro-1,1-difluoroheptane
N-methyl-1-(4-methyl-1H-imidazol-5-yl)cyclopropan-1-amine
N-[(4-methylnaphthalen-1-yl)methyl]hydroxylamine
1-{1-[4-(Methylsulfanyl)phenyl]cyclopropyl}ethan-1-one
4-Fluoro-1-(2-isocyanatopropan-2-yl)-2-methoxybenzene
Methyl 3-hydroxy-3-(2-hydroxyphenyl)propanoate
2-[(6-Chloropyridin-2-yl)oxy]ethan-1-amine hydrochloride
1-[(3-Methoxy-2-methylphenyl)methyl]cyclopropane-1-carboxylic acid

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