Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro-

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Names

[ CAS No. ]:
2482-80-6

[ Name ]:
Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro-

[Synonym ]:
2,4-Bis-aziridin-1-yl-6-chlor-pyrimidin
Ethymidine
Aethimidinum
2,4-Diethylenimino-6-chloropyrimidine
2,4-bis-aziridin-1-yl-6-chloro-pyrimidine
Etimidin
Ethimidine
2,6-Diethylenimino-4-chloropyrimidine
Aethimidinium

Chemical & Physical Properties

[ Density]:
1.561g/cm3

[ Boiling Point ]:
410.4ºC at 760mmHg

[ Molecular Formula ]:
C8H9ClN4

[ Molecular Weight ]:
196.63700

[ Flash Point ]:
202ºC

[ Exact Mass ]:
196.05200

[ PSA ]:
31.80000

[ LogP ]:
0.90000

[ Vapour Pressure ]:
6.06E-07mmHg at 25°C

[ Index of Refraction ]:
1.711

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV7065000
CHEMICAL NAME :
Pyrimidine, 2,4-bis(1-aziridinyl)-6-chloro-
CAS REGISTRY NUMBER :
2482-80-6
BEILSTEIN REFERENCE NO. :
0188373
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C8-H9-Cl-N4
MOLECULAR WEIGHT :
196.66
WISWESSER LINE NOTATION :
T6N CNJ DG B- AT3NTJ& F- AT3NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - change in acuity Gastrointestinal - nausea or vomiting Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - change in acuity Gastrointestinal - nausea or vomiting Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1350 ug/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
2500 ug/kg
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 6,357,1951

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 1,3,5-Triazine, 2,4-bis(1-aziridinyl)-6-chloro-
  • 2,4-bis(aziridin-1-yl)-5-chloro-6-methoxypyrimidine
  • 2,4-bis(aziridin-1-yl)-5,6-dichloropyrimidine
  • 4-(aziridin-1-yl)-6-chloropyrimidine
  • Pyrimidine,2,4-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-fluoro-
  • Pyrimidine,4-(1-aziridinyl)-6-(methylsulfonyl)-
  • Phosphonic acid, [(2S)-2-amino-2-(4-fluorophenyl)ethyl]-, diethyl ester
  • 2,2-dimethyl-N-[2-(3-methylphenyl)-4-oxo-4H-chromen-6-yl]propanamide
  • N1-(3,3-diphenylpropyl)-N2-(4-fluorobenzyl)oxalamide
  • (E)-1-amino-2,4-pentadiene
  • 2-(4-(2-fluorophenyl)piperazin-1-yl)-N-(3-(methylthio)phenyl)-2-oxoacetamide
  • N1-(4-chlorophenethyl)-N2-(2-(methylthio)phenyl)oxalamide
  • 3-Bromo-N-cyclohexyl-6-phenyl-imidazo[1,2-a]pyrazin-8-amine
  • (Rp)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl phenylphosphinate
  • 2-Ethoxycinnamoyl chloride
  • 6,7-dimethoxy-N-naphthalen-2-ylquinazolin-4-amine
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