Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro-

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Names

[ CAS No. ]:
2482-80-6

[ Name ]:
Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro-

[Synonym ]:
2,4-Bis-aziridin-1-yl-6-chlor-pyrimidin
Ethymidine
Aethimidinum
2,4-Diethylenimino-6-chloropyrimidine
2,4-bis-aziridin-1-yl-6-chloro-pyrimidine
Etimidin
Ethimidine
2,6-Diethylenimino-4-chloropyrimidine
Aethimidinium

Chemical & Physical Properties

[ Density]:
1.561g/cm3

[ Boiling Point ]:
410.4ºC at 760mmHg

[ Molecular Formula ]:
C8H9ClN4

[ Molecular Weight ]:
196.63700

[ Flash Point ]:
202ºC

[ Exact Mass ]:
196.05200

[ PSA ]:
31.80000

[ LogP ]:
0.90000

[ Vapour Pressure ]:
6.06E-07mmHg at 25°C

[ Index of Refraction ]:
1.711

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV7065000
CHEMICAL NAME :
Pyrimidine, 2,4-bis(1-aziridinyl)-6-chloro-
CAS REGISTRY NUMBER :
2482-80-6
BEILSTEIN REFERENCE NO. :
0188373
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C8-H9-Cl-N4
MOLECULAR WEIGHT :
196.66
WISWESSER LINE NOTATION :
T6N CNJ DG B- AT3NTJ& F- AT3NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - change in acuity Gastrointestinal - nausea or vomiting Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - change in acuity Gastrointestinal - nausea or vomiting Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1350 ug/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
2500 ug/kg
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 6,357,1951

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 1,3,5-Triazine, 2,4-bis(1-aziridinyl)-6-chloro-
  • 2,4-bis(aziridin-1-yl)-5-chloro-6-methoxypyrimidine
  • 2,4-bis(aziridin-1-yl)-5,6-dichloropyrimidine
  • 4-(aziridin-1-yl)-6-chloropyrimidine
  • Pyrimidine,2,4-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-fluoro-
  • Pyrimidine,4-(1-aziridinyl)-6-(methylsulfonyl)-
  • (3-Methyl-1,2-oxazol-5-YL)methanol; acetic acid
  • 2-Acetamido-1,3-DI-O-acetyl-2-deoxy-D-glucopyranose
  • N-((2-(dimethylamino)-6-methylpyrimidin-4-yl)methyl)pentanamide
  • 4-Chloro-2-(4-isopropoxyphenyl)-7-methoxyquinoline
  • N-(7-Bromo-1H-benzo[d]imidazol-5-yl)acetamide
  • 5-Bromo-3-acetamidopyridine-2-carboxylic acid
  • 5-Chloro-4-methoxyisoquinolin-1(2H)-one
  • 1(2H)-Isoquinolinone, 6-methoxy-3-(trifluoromethyl)-
  • 4-(Difluoromethyl)-2-ethynylpyrimidine
  • 3-(Benzyl(methyl)amino)-6-methoxyisoquinolin-1-ol
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