Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro-

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Names

[ CAS No. ]:
2482-80-6

[ Name ]:
Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro-

[Synonym ]:
2,4-Bis-aziridin-1-yl-6-chlor-pyrimidin
Ethymidine
Aethimidinum
2,4-Diethylenimino-6-chloropyrimidine
2,4-bis-aziridin-1-yl-6-chloro-pyrimidine
Etimidin
Ethimidine
2,6-Diethylenimino-4-chloropyrimidine
Aethimidinium

Chemical & Physical Properties

[ Density]:
1.561g/cm3

[ Boiling Point ]:
410.4ºC at 760mmHg

[ Molecular Formula ]:
C8H9ClN4

[ Molecular Weight ]:
196.63700

[ Flash Point ]:
202ºC

[ Exact Mass ]:
196.05200

[ PSA ]:
31.80000

[ LogP ]:
0.90000

[ Vapour Pressure ]:
6.06E-07mmHg at 25°C

[ Index of Refraction ]:
1.711

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV7065000
CHEMICAL NAME :
Pyrimidine, 2,4-bis(1-aziridinyl)-6-chloro-
CAS REGISTRY NUMBER :
2482-80-6
BEILSTEIN REFERENCE NO. :
0188373
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C8-H9-Cl-N4
MOLECULAR WEIGHT :
196.66
WISWESSER LINE NOTATION :
T6N CNJ DG B- AT3NTJ& F- AT3NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - change in acuity Gastrointestinal - nausea or vomiting Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - change in acuity Gastrointestinal - nausea or vomiting Tumorigenic - active as anti-cancer agent
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1350 ug/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
2500 ug/kg
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 6,357,1951

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 1,3,5-Triazine, 2,4-bis(1-aziridinyl)-6-chloro-
  • 2,4-bis(aziridin-1-yl)-5-chloro-6-methoxypyrimidine
  • 2,4-bis(aziridin-1-yl)-5,6-dichloropyrimidine
  • 4-(aziridin-1-yl)-6-chloropyrimidine
  • Pyrimidine,2,4-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-fluoro-
  • Pyrimidine,4-(1-aziridinyl)-6-(methylsulfonyl)-
  • 2-(3-methoxyphenyl)-2-oxoethyl 2-oxo-2H-chromene-3-carboxylate
  • N-(3,4-dimethylphenyl)-4-(2-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
  • 4-(2,4-dichlorophenyl)-N-(3,4-dimethylphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
  • 4-(3-bromophenyl)-N-(3,4-dimethylphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
  • 4-(2-chlorophenyl)-N-(3,4-dimethylphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
  • N-(2-fluorophenyl)-4-(4-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
  • 3-((2-chlorobenzyl)thio)-5-methyl-4H-1,2,4-triazole
  • N-(3,4-dimethoxyphenyl)quinazolin-4-amine
  • 5-Ethyl-2,3-dimethylfuran
  • Ethyl 4-(2-((2-(methoxycarbonyl)phenyl)amino)-2-oxoethyl)piperazine-1-carboxylate
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