Destruxin B

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Names

[ CAS No. ]:
2503-26-6

[ Name ]:
Destruxin B

[Synonym ]:
destruxin B

Chemical & Physical Properties

[ Density]:
1.17g/cm3

[ Boiling Point ]:
875ºC at 760mmHg

[ Molecular Formula ]:
C₃₂H₅₅N₅O₇

[ Molecular Weight ]:
593.75500

[ Flash Point ]:
483ºC

[ Exact Mass ]:
593.37900

[ PSA ]:
145.43000

[ LogP ]:
1.78730

[ Vapour Pressure ]:
4.15E-31mmHg at 25°C

[ Index of Refraction ]:
1.535

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HH1500100

CHEMICAL NAME :: Destruxin B

CAS REGISTRY NUMBER :: 2503-26-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C30-H51-N5-O7

MOLECULAR WEIGHT :: 593.86

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16900 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - coma

REFERENCE :: ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 26,36,1962

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(R)-Leucic acid
tert-butyl 2-((S)-2-((S)-N,3-dimethyl-2-(methylamino)butanamido)propanoyl)hydrazinecarboxylate
L-Proline, phenylmethylester
benzyl ((R)-2-((3-((tert-butoxycarbonyl)amino)propanoyl)oxy)-4-methylpentanoyl)-L-prolinate
tert-butyl 2-(N-(N-((R)-2-hydroxy-4-methylpentanoyl)-L-prolyl-L-isoleucyl-N-methyl-L-valyl)-N-methyl-L-alanyl)hydrazine-1-carboxylate