5-hydroxyindomethacin

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Names

[ CAS No. ]:
2504-32-7

[ Name ]:
5-hydroxyindomethacin

[Synonym ]:
2-[1-(4-chlorobenzoyl)-5-hydroxy-2-methylindol-3-yl]acetic acid

Chemical & Physical Properties

[ Density]:
1.4g/cm3

[ Boiling Point ]:
518.8ºC at 760mmHg

[ Melting Point ]:
217-219ºC

[ Molecular Formula ]:
C18H14ClNO4

[ Molecular Weight ]:
343.76100

[ Flash Point ]:
267.6ºC

[ Exact Mass ]:
343.06100

[ PSA ]:
79.53000

[ LogP ]:
3.62430

[ Vapour Pressure ]:
1.37E-11mmHg at 25°C

[ Index of Refraction ]:
1.651

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Indometacin
  • tert-butyl 2-(1-(4-chlorobenzoyl)-5-hydroxy-2-methyl-1H-indol-3-yl)acetate
  • tert-butyl 4-oxopentanoate
  • 4-Benzyloxyphenylhydrazine hydrochloride
  • t-butyl 5-benzyloxy-2-methyl indole acetate

DownStream

Related Compounds

  • 5-[(4-phenylphenyl)methylidene]imidazolidine-2,4-dione
  • 5-(3-formyl-2-hydroxyphenyl)benzene-1,3-dicarboxylic acid
  • 5,8-difluoro-4-methyl-1,2,3,4-tetrahydronaphthalen-1-ol
  • 5-(p-Toluenesulfonate)-2,3-O-isopropylidene-2-C-methyl-D-ribonic-gamma-lactone
  • 5-(oxiran-2-ylmethoxy)-2,3,4,9-tetrahydro-1H-carbazole
  • 5-(2,4-difluorophenyl)-2-hydroxy-3-sulfooxybenzoic acid
  • rac-(3aR,6aR)-2-(trifluoroacetyl)-octahydrocyclopenta[c]pyrrole-3a-carboxylic acid
  • Benzyl 5-chloro-1,2,3,6-tetrahydropyridine-1-carboxylate
  • 5-(trifluoroacetyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazine-3-carboxylic acid
  • Benzyl 4-hydroxy-3,5-dimethylpiperidine-1-carboxylate
  • 2-(Trifluoroacetyl)-octahydropyrano[3,4-c]pyrrole-7a-carboxylic acid
  • 2-{[(tert-butoxy)carbonyl]amino}-3-[1-(propan-2-yl)-1H-1,2,3-triazol-4-yl]propanoic acid
  • benzyl N-(piperazine-1-sulfonyl)carbamate
  • tert-butyl N-(4-fluoro-3-propanoylphenyl)carbamate
  • 3-Methyl-1-[(prop-2-en-1-yloxy)carbonyl]azetidine-3-carboxylic acid
  • tert-butyl N-[3-(2-methylpropanoyl)phenyl]carbamate