gloxazone

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Names

[ CAS No. ]:
2507-91-7

[ Name ]:
gloxazone

[Synonym ]:
WR 9838
Gloxazon
2-Keto-3-aethoxy-butyraldehyd-bis-thiosemicarbazon
3-Aethoxy-2-keto-butyraldehyd-bis-thiosemicarbazon
GLOXAZONE
BW 356C61
KTS,pharmaceutical
KC 1331
KTS
3-Aethoxy-butan-1,2-dion-bis-thiosemicarbazon
3-Ethoxy-2-oxobutyraldehyde bis-thiosemicarbazone
Contrapar

Chemical & Physical Properties

[ Density]:
1.41g/cm3

[ Boiling Point ]:
419.7ºC at 760mmHg

[ Molecular Formula ]:
C8H16N6OS2

[ Molecular Weight ]:
276.38200

[ Flash Point ]:
207.6ºC

[ Exact Mass ]:
276.08300

[ PSA ]:
174.23000

[ LogP ]:
1.60200

[ Vapour Pressure ]:
2.97E-07mmHg at 25°C

[ Index of Refraction ]:
1.645

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ES2450000
CHEMICAL NAME :
Butyraldehyde, 3-ethoxy-2-oxo-, bis(thiosemicarbazone)
CAS REGISTRY NUMBER :
2507-91-7
LAST UPDATED :
199612
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C8-H16-N6-O-S2
MOLECULAR WEIGHT :
276.42
WISWESSER LINE NOTATION :
SUYZMNUYY1&O2&1UNMYZUS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>3200 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
440 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
195 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
182 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1600 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
475 mg/kg/5D-I
TOXIC EFFECTS :
Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
190 mg/kg/5D-I
TOXIC EFFECTS :
Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg/5D-I
TOXIC EFFECTS :
Behavioral - ataxia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
100 mg/kg/10D-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
90 mg/kg/30D-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
250 mg/kg/10D-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
300 mg/kg/10D-I
TOXIC EFFECTS :
Behavioral - coma Endocrine - hypoglycemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
300 mg/kg/30D-I
TOXIC EFFECTS :
Endocrine - hypoglycemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human HeLa cell
DOSE/DURATION :
50 umol/l
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 92,427,1982

Safety Information

[ HS Code ]:
2930909090

Synthetic Route

Precursor & DownStream

Precursor

  • Thiosemicarbazide
  • 3-ethoxy-2-oxobutyraldehyde

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%


Related Compounds

  • 2-Cyclopropyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-amine
  • 6-chloro-5-(5-phenylpyrazin-2-yl)-1H-indole-3-carboxylic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • Imidazo[1,2-a]pyridine-6-sulfonyl chloride
  • 2-Amino-1-[3-(methoxymethyl)phenyl]propan-1-one
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • Ethyl 2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetate
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (3-((3-Cyclopropyl-1,2,4-oxadiazol-5-yl)methyl)piperidin-1-yl)(6-(trifluoromethyl)pyridin-3-yl)methanone