20(S)-Camptothecin sodium salt

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Names

[ CAS No. ]:
25387-67-1

[ Name ]:
20(S)-Camptothecin sodium salt

[Synonym ]:
camptothecinsodium
camptothecin,sodiumsalt
21,22-Secocamptothecin-21-oic acid,monosodium salt 20(S)-camptothecin sodium salt
Fda 1660
21,22-secocamptothecin-21-oicacid,monosodiumsalt
20(s)-camptothecinsodiumsalt
camptothecin Na
camptothecinesodium
CaMphotecin sodiuM

Chemical & Physical Properties

[ Boiling Point ]:
777.3ºC at 760 mmHg

[ Molecular Formula ]:
C20H17N2NaO5

[ Molecular Weight ]:
388.34900

[ Flash Point ]:
423.9ºC

[ Exact Mass ]:
388.10400

[ PSA ]:
115.48000

[ LogP ]:
0.26500

[ Vapour Pressure ]:
1.96E-25mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EX1650000
CHEMICAL NAME :
Camptothecin, sodium salt
CAS REGISTRY NUMBER :
25387-67-1
LAST UPDATED :
199706
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C20-H18-N2-O5.Na
MOLECULAR WEIGHT :
389.39
WISWESSER LINE NOTATION :
T F6 D6 C566 BN HVO LVN NHT&&&&J GQ G2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
2500 ug/kg/7D-I
TOXIC EFFECTS :
Blood - leukopenia Blood - thrombocytopenia Blood - changes in cell count (unspecified)
REFERENCE :
CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 56,515,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
27 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
151 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTKRDX Gan to Kagaku Ryoho. Cancer and Chemotherapy. (1-8-9 Yaesu, Chuo-ku, Tokyo 103, Japan) V.1- 1974- Volume(issue)/page/year: 14,850,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
57 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973

Safety Information

[ Hazard Codes ]:
T+

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Campathecin

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • GTP-GAMMA-S SODIUM SALT
  • 7-propyl-20(S)-camptothecin
  • RP-UTP-ALPHA-S SODIUM SALT
  • Piperidine-1-thiocarboxylic acid S-sodium salt
  • Dithiocarbonic acid O-methyl S-sodium salt
  • Dithiocarbonic acid O-(2-methylbutyl)S-sodium salt
  • 4-Methyl-6-(propylamino)nicotinonitrile
  • 5-Bromo-2-(tert-butylamino)nicotinic acid
  • 4-Methyl-6-(propylamino)nicotinic acid
  • 5-Bromo-2-[(2-methylpropyl)amino]-3-pyridinecarboxylic acid
  • 1-(4-Methyl-6-(propylamino)pyridin-3-yl)propan-1-one
  • 2-tert-Butyl-4-cyclobutyl-6-(piperazin-1-yl)pyrimidine
  • Methyl 6-(ethyl(methyl)amino)-4-methylnicotinate
  • Ethyl 4-hydroxy-1,2,5-trimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate
  • 6-(Ethyl(methyl)amino)-4-methylnicotinonitrile
  • 3-Bromo-1-[(1-ethyl-1H-pyrazol-3-yl)methyl]-4-nitro-1H-indazole