20(S)-Camptothecin sodium salt
Suppliers
Names
[ CAS No. ]:
25387-67-1
[ Name ]:
20(S)-Camptothecin sodium salt
[Synonym ]:
camptothecinsodium
camptothecin,sodiumsalt
21,22-Secocamptothecin-21-oic acid,monosodium salt 20(S)-camptothecin sodium salt
Fda 1660
21,22-secocamptothecin-21-oicacid,monosodiumsalt
20(s)-camptothecinsodiumsalt
camptothecin Na
camptothecinesodium
CaMphotecin sodiuM
Chemical & Physical Properties
[ Boiling Point ]:
777.3ºC at 760 mmHg
[ Molecular Formula ]:
C20H17N2NaO5
[ Molecular Weight ]:
388.34900
[ Flash Point ]:
423.9ºC
[ Exact Mass ]:
388.10400
[ PSA ]:
115.48000
[ LogP ]:
0.26500
[ Vapour Pressure ]:
1.96E-25mmHg at 25°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EX1650000
- CHEMICAL NAME :
- Camptothecin, sodium salt
- CAS REGISTRY NUMBER :
- 25387-67-1
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C20-H18-N2-O5.Na
- MOLECULAR WEIGHT :
- 389.39
- WISWESSER LINE NOTATION :
- T F6 D6 C566 BN HVO LVN NHT&&&&J GQ G2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 2500 ug/kg/7D-I
- TOXIC EFFECTS :
- Blood - leukopenia Blood - thrombocytopenia Blood - changes in cell count (unspecified)
- REFERENCE :
- CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 56,515,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 27 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 151 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GTKRDX Gan to Kagaku Ryoho. Cancer and Chemotherapy. (1-8-9 Yaesu, Chuo-ku, Tokyo 103, Japan) V.1- 1974- Volume(issue)/page/year: 14,850,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 57 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973
Safety Information
[ Hazard Codes ]:
T+
[ HS Code ]:
2942000000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%