20(S)-Camptothecin sodium salt

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Names

[ Name ]:
20(S)-Camptothecin sodium salt

[Synonym ]:
camptothecinsodium
camptothecin,sodiumsalt
21,22-Secocamptothecin-21-oic acid,monosodium salt 20(S)-camptothecin sodium salt
Fda 1660
21,22-secocamptothecin-21-oicacid,monosodiumsalt
20(s)-camptothecinsodiumsalt
camptothecin Na
camptothecinesodium
CaMphotecin sodiuM

Chemical & Physical Properties

[ Boiling Point ]:
777.3ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₇N₂NaO₅

[ Molecular Weight ]:
388.34900

[ Flash Point ]:
423.9ºC

[ Exact Mass ]:
388.10400

[ PSA ]:
115.48000

[ LogP ]:
0.26500

[ Vapour Pressure ]:
1.96E-25mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EX1650000

CHEMICAL NAME :: Camptothecin, sodium salt

CAS REGISTRY NUMBER :: 25387-67-1

LAST UPDATED :: 199706

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H18-N2-O5.Na

MOLECULAR WEIGHT :: 389.39

WISWESSER LINE NOTATION :: T F6 D6 C566 BN HVO LVN NHT&&&&J GQ G2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 2500 ug/kg/7D-I

TOXIC EFFECTS :: Blood - leukopenia Blood - thrombocytopenia Blood - changes in cell count (unspecified)

REFERENCE :: CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 56,515,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 151 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTKRDX Gan to Kagaku Ryoho. Cancer and Chemotherapy. (1-8-9 Yaesu, Chuo-ku, Tokyo 103, Japan) V.1- 1974- Volume(issue)/page/year: 14,850,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 57 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973

Safety Information

[ Hazard Codes ]:
T+

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

GTP-GAMMA-S SODIUM SALT
7-propyl-20(S)-camptothecin
RP-UTP-ALPHA-S SODIUM SALT
Piperidine-1-thiocarboxylic acid S-sodium salt
Dithiocarbonic acid O-methyl S-sodium salt
Dithiocarbonic acid O-(2-methylbutyl)S-sodium salt
tert-butyl N-[(3,5-difluoro-4-hydroxyphenyl)methyl]carbamate
(S)-(4-(1-Aminobutyl)-3-fluorophenyl)methanol
8-(6-Chloro-1,3-benzothiazol-2-yl)-1,4-dioxa-8-azaspiro[4.5]decane
4-(Phenylsulfonyl)-8-(2-pyrimidinyl)-1-oxa-4,8-diazaspiro[4.5]decane
6-Chloro-7-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole
1-Cyclohexyl-3-[1-(oxan-4-yl)azetidin-3-yl]urea
2,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide
2,5-Difluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
(2,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
5-(1,3-Benzodioxol-4-yl)-4-isoxazolecarboxylic acid

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