5-O-Triphenylmethyl-2-deoxy-2,3-didehyrothymidine

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Names

[ CAS No. ]:
25442-42-6

[ Name ]:
5-O-Triphenylmethyl-2-deoxy-2,3-didehyrothymidine

[Synonym ]:
2,5-Methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one, 2,3-dihydro-8-methyl-3-[(triphenylmethoxy)methyl]-, (2R,3R,5R)-
(1R,9R,10R)-4-Methyl-10-[(trityloxy)methyl]-8,11-dioxa-2,6-diazatricyclo[7.2.1.0]dodeca-3,6-dien-5-one
5-O-Triphenylmethyl-2-deoxy-2,3-didehyrothymidine
5-Methyl-1-{(2R,5S)-5-[(trityloxy)methyl]-2,5-dihydro-2-furanyl}-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 1-[(2R,5S)-2,5-dihydro-5-[(triphenylmethoxy)methyl]-2-furanyl]-5-methyl-

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
595.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H26N2O4

[ Molecular Weight ]:
466.528

[ Flash Point ]:
314.1±32.9 °C

[ Exact Mass ]:
466.189270

[ PSA ]:
62.58000

[ LogP ]:
5.59

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.617

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5'-O-Tritylthymidine
  • 5-methyl-1-[4-methylsulfonyloxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
  • 1-[(2R,4S,5R)-4-iodo-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
  • Triphenylmethyl Chloride
  • Thymidine
  • Ethanol

DownStream

  • 3'-Amino-3'-deoxythymidine
  • Stavudine
  • 1-[(2R,4R,5R)-4-fluoro-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
  • Alovudine
  • 5'-o-trityl-2',3'-dehydrothymidine
  • 5'-O-TRITYL-2'-DEOXY-BETA-D-LYXOFURANOSYLTHYMINE
  • 2-Amino-9-[(2R,4S,5S)-4-amino-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one

Related Compounds

  • 9H-Purine, 9-[3-O-benzoyl-2-deoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-arabinofuranosyl]-6-chloro-
  • 5-O-benzoyl-2-deoxy-2,2-difluoro-3-O-(p-phenylbenzoyl)-α-D-ribofuranosyl bromide
  • 5-O-Benzoyl-2-deoxy-2-fluoro-1-O-methyl-3-O-(methylthio)thiocarbonyl-β-D-arabinofuranose
  • 5-O-Benzoyl-2-deoxy-2-fluoro-1-O-methyl-β-D-arabinofuranose
  • 5-O-(Triphenylmethyl)-2-C-methyl-D-ribonic-γ-lactone
  • 5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-β-D-ribofuranosyl chloride
  • 4-(2-(1H-pyrazol-1-yl)ethyl)-N-(3,4-dichlorophenyl)piperazine-1-carboxamide
  • 4-(2-(1H-pyrazol-1-yl)ethyl)-N-(4-fluorophenyl)piperazine-1-carboxamide
  • 4-(2-(1H-pyrazol-1-yl)ethyl)-N-(o-tolyl)piperazine-1-carboxamide
  • 4-(2-(1H-pyrazol-1-yl)ethyl)-N-(3-phenylpropyl)piperazine-1-carboxamide
  • 1-[(5-methylthiophen-2-yl)sulfonyl]-4-[2-(1H-pyrazol-1-yl)ethyl]piperazine
  • 1-(2-(1H-pyrazol-1-yl)ethyl)-4-((2-ethoxyphenyl)sulfonyl)piperazine
  • 1-(2-(1H-pyrazol-1-yl)ethyl)-4-(isopropylsulfonyl)piperazine
  • 4-(2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl)-N-(4-methoxyphenethyl)piperazine-1-carboxamide
  • 5-(4-Fluorobenzoyl)-octahydropyrrolo[3,4-b]pyrrole
  • 2-[3-[3-(3-Chlorophenyl)-1,2,4-oxadiazol-5-yl]azetidin-1-yl]-N-(oxolan-2-ylmethyl)acetamide
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