Alovudine

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Names

[ CAS No. ]:
25526-93-6

[ Name ]:
Alovudine

[Synonym ]:
MFCD00056058
3,-Deoxy-3,-fluoro Thymidine
Thymidine, 3'-deoxy-3'-fluoro-
Alovudine

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Melting Point ]:
176-178ºC(lit.)

[ Molecular Formula ]:
C10H13FN2O4

[ Molecular Weight ]:
244.22

[ Exact Mass ]:
244.085938

[ PSA ]:
84.32000

[ LogP ]:
-0.52

[ Index of Refraction ]:
1.565

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XP2073000
CHEMICAL NAME :
Thymidine, 3'-deoxy-3'-fluoro-
CAS REGISTRY NUMBER :
25526-93-6
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H13-F-N2-O4
MOLECULAR WEIGHT :
244.25
WISWESSER LINE NOTATION :
T6NVMVJ E1 A- ET5OTJ B1Q CF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - mouse Ascites tumor
DOSE/DURATION :
10 umol/L
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 32,178,1977

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-[(2R,4R,5R)-4-fluoro-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
  • ((2R,3R,4S)-4-chloro-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl benzoate
  • 5-O-Triphenylmethyl-2-deoxy-2,3-didehyrothymidine
  • 1-(2-chloro-2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)thymine
  • [(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate
  • methyl 5-O-benzyl-2-O-tosyl-3-fluoro-3-deoxy-β-D-arabino-furanoside
  • 2,5-Methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one,2,3-dihydro-3-(hydroxymethyl)-8-methyl-, (2R,3R,5R)-
  • methyl 5-O-benzyl-2-chloro-2,3-dideoxy-3-fluoro-β-D-ribofuranoside

DownStream

Related Compounds

  • 3-((1H-Benzo[d]imidazol-1-yl)imino)indolin-2-one
  • rac-(3aS,6aS)-N-quinolin-5-ylhexahydropyrrolo[3,4-b]pyrrole-1(2H)-carboxamide
  • 7-Chloro-2-{[(prop-2-yn-1-yl)amino]methyl}-3,4-dihydroquinazolin-4-one
  • 5-(aminomethyl)-1,3-dimethyl-1H,6H,7H-pyrazolo[3,4-b]pyridin-6-one
  • 4-Methoxypyridine-3-sulfonyl fluoride
  • 4-[(5,6-Diphenylpyrazin-2-yl)methylamino]butan-1-ol
  • 6-Bromo-3-cyano-2-formylbenzoic acid
  • (Z)-2-((E)-((1H-indol-3-yl)methylene)hydrazono)-5-(2-oxo-2-phenylethyl)thiazolidin-4-one
  • (R)-1-(2-Bromopyridin-4-YL)-2,2,2-trifluoroethan-1-amine
  • 7-bromo-6-chlorothieno[3,2-d]pyrimidin-4(3H)-one
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