8-Acetyl-7-hydroxy-4-methyl-chromen-2-one

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Names

[ CAS No. ]:
2555-29-5

[ Name ]:
8-Acetyl-7-hydroxy-4-methyl-chromen-2-one

[Synonym ]:
8-Acetyl-7-hydroxy-4-methylcoumarin
4-Methyl-7-hydroxy-8-acetylcoumarin
COUMARIN,8-ACETYL-7-HYDROXY-4-METHYL
8-acetyl-7-hydroxy-4-methyl-2H-1-benzopyran-2-one
7-hydroxy-8-acetyl-4-methyl-chromen-2-one
8-Acetyl-4-methylumbelliferone
MFCD00100602
8-Acetyl-7-hydroxy-4-methyl-2H-chromen-2-one
4-methyl-7-hydroxyl-8-acetylcoumarin
2H-1-Benzopyran-2-one, 8-acetyl-7-hydroxy-4-methyl-
8-Acetyl-7-hydroxy-4-methyl-chromen-2-one
8-acetyl-4-methyl-7-hydroxycoumarin

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
426.1±45.0 °C at 760 mmHg

[ Melting Point ]:
174-178°C

[ Molecular Formula ]:
C12H10O4

[ Molecular Weight ]:
218.205

[ Flash Point ]:
170.7±22.2 °C

[ Exact Mass ]:
218.057907

[ PSA ]:
67.51000

[ LogP ]:
2.66

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.599

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GN4910000
CHEMICAL NAME :
Coumarin, 8-acetyl-7-hydroxy-4-methyl-
CAS REGISTRY NUMBER :
2555-29-5
BEILSTEIN REFERENCE NO. :
0195795
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C12-H10-O4
MOLECULAR WEIGHT :
218.22
WISWESSER LINE NOTATION :
T66 BOVJ E1 IQ JV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
910 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 21,555,1958

Safety Information

[ RTECS ]:
GN4910000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 7-Acetoxy-4-methylcoumarin
  • 4-Methylumbelliferone
  • Ethanoic anhydride
  • 2,6-Dihydroxyacetophenone
  • Ethyl acetoacetate
  • Resorcine
  • 8-acetyl-4-methyl-2-oxo-2H-chromen-7-yl acetate
  • 8-acetyl-7-((β-chloroallyl)oxy)-4-methylcoumarin
  • (4-methyl-2-oxochromen-7-yl) benzoate
  • m-Xylene

DownStream

  • 5-Hydroxyflavone
  • methyl 3-amino-2-cyano-3-iodoprop-2-enoate
  • 2,6-Dihydroxyacetophenone
  • 1-(2-Hydroxy-6-methoxyphenyl)ethanone
  • 2',6'-Dimethoxyacetophenone
  • 8-acetyl-7-[3-(bis(2-hydroxyethyl)amino)-2-hydroxy-propoxy]-4-methyl-chromen-2-one
  • 2H-1-Benzopyran-2-one,8-acetyl-7-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-4-methyl-
  • 8-acetyl-7-methoxy-4-methylchromen-2-one
  • 8-[1-(hydroxyamino)ethylidene]-4-methylchromene-2,7-dione
  • 8-acetyl-7-hydroxy-4-methyl-6-prop-2-enylchromen-2-one

Related Compounds

  • 8-acetyl-7-hydroxy-4-methyl-6-prop-2-enylchromen-2-one
  • 8-Dimethylaminomethyl-7-hydroxy-4-methyl-chromen-2-one; compound with nicotinic acid
  • 8-Dimethylaminomethyl-7-hydroxy-4-methyl-chromen-2-one; compound with pyridine-2-carboxylic acid
  • 8-acetyl-7-hydroxy-4-phenyl-2H-chromen-2-one
  • 8-acetyl-7-[3-(bis(2-hydroxyethyl)amino)-2-hydroxy-propoxy]-4-methyl-chromen-2-one
  • 8-acetyl-3-bromo-7-hydroxy-4-methylcoumarin
  • Tert-butyl 4-{[3-azido-5-(piperazin-1-yl)phenyl]methyl}piperazine-1-carboxylate
  • Tert-butyl 4-{3-azido-5-[(piperazin-1-yl)methyl]phenyl}piperazine-1-carboxylate
  • 3-Amino-5-(azidomethyl)benzene-1-sulfonyl fluoride
  • Methyl 3-{[2-(tert-butoxy)-2-oxoethoxy]methyl}-5-sulfanylbenzoate
  • 3-{[2-(Tert-butoxy)-2-oxoethoxy]methyl}-5-sulfanylbenzoic acid
  • 2-(3-{4-[(Tert-butoxy)carbonyl]piperazin-1-yl}-2,4,6-trimethyl-5-[2-(trimethylsilyl)ethynyl]phenyl)acetic acid
  • Tert-butyl 4-[(3-amino-5-iodo-2,4,6-trimethylphenyl)methyl]piperazine-1-carboxylate
  • tert-butyl N-{3-iodo-2,4,6-trimethyl-5-[(piperazin-1-yl)methyl]phenyl}carbamate
  • 2-(3-{4-[(Tert-butoxy)carbonyl]piperazin-1-yl}-5-[(fluorosulfonyl)oxy]-2,4,6-trimethylphenyl)acetic acid
  • Tert-butyl 4-{3-[(fluorosulfonyl)oxy]-5-(methoxycarbonyl)-2,4,6-trimethylphenyl}piperazine-1-carboxylate
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