1-Ethynyl-3-fluorobenzene

Names

[ Name ]:
1-Ethynyl-3-fluorobenzene

[Synonym ]:
1-Ethynyl-3-fluorobenzene
1-(1-ethynyl)-3-fluorobenzene
Benzene, 1-ethynyl-3-fluoro-
3-F-phenylacetylene
(3-fluorophenyl)acetylene
1-fluoro-3-ethynylbenzene
3-FC6H4CCH
MFCD03093798

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
148.7±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₅F

[ Molecular Weight ]:
120.124

[ Flash Point ]:
26.2±15.7 °C

[ Exact Mass ]:
120.037529

[ LogP ]:
2.45

[ Vapour Pressure ]:
5.3±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.516

MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R10;R36/37/38

[ Safety Phrases ]:
S16-S26-S36

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

[(3-Fluorophenyl)ethynyl](trimethyl)silane
(Z)-1-(2-bromovinyl)-3-fluorobenzene
1-(3-Fluorophenyl)ethanol
3-Fluorostyrene
3-Fluorophenylmagnesium bromide solution
1-Bromo-3-fluorobenzene
Fluorobenzene

DownStream

3-Fluorobenzoic acid
1-(3-Fluorophenyl)ethanone
3-Fluorostyrene
4-(3-FLUOROPHENYL)THIAZOL-2-AMINE
1-fluoro-3-(2-phenylethynyl)benzene
3-Fluorophenethylalcohol
(3-Fluorophenyl)acetaldehyde
3-Nitroaniline
Isobutylboronic acid pinacol ester

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

N-trifluoromethylthiosaccharin: an easily accessible, shelf-stable, broadly applicable trifluoromethylthiolating reagent.

Angew. Chem. Int. Ed. Engl. 53(35) , 9316-20, (2014)

A new, electrophilic trifluoromethylthiolating reagent, N-trifluoromethylthiosaccharin, was developed and can be synthesized in two steps from saccharin within 30 minutes. N-trifluoromethylthiosacchar...

Copper-catalyzed amine-alkyne-alkyne addition reaction: an efficient method for the synthesis of gamma,delta-alkynyl-beta-amino acid derivatives.

Chemistry 15(43) , 11668-74, (2009)

A simple and efficient method for the synthesis of gamma,delta-alkynyl-beta-amino acid derivatives by a copper-catalyzed three-component amine-alkyne-alkyne addition reaction was developed. Various ga...

Gold film-catalysed benzannulation by microwave-assisted, continuous flow organic synthesis (MACOS).

.PubMed ID

Methodology has been developed for laying down a thin gold-on-silver film on the inner surface of glass capillaries for the purpose of catalysing benzannulation reactions. The cycloaddition precursors...

1-Ethynyl-3,4-fluorobenzene
1-ethynyl-3-isopropoxy-benzene
1-ethynyl-3-(prop-2-enoxymethyl)benzene
1-ethynyl-3-methoxy-2-(methoxymethoxy)benzene
1-Ethynyl-3-(trifluoromethoxy)-benzene
1-ethynyl-3-[4-[4-(3-ethynylphenoxy)phenyl]sulfonylphenoxy]benzene
3-(((3-((3-(Pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)methyl)piperidin-1-yl)sulfonyl)methyl)benzo[d]isoxazole
1-[4-Fluoro-2-(trifluoromethyl)phenyl]-2-(methylamino)ethan-1-ol
N-(2-(2-(pyridin-2-yl)-1H-imidazol-1-yl)ethyl)-2-(o-tolyloxy)acetamide
2-(2,5-Difluoro-4-methylphenyl)propanenitrile
2-(benzylthio)-N-(2-(2-(pyridin-2-yl)-1H-imidazol-1-yl)ethyl)acetamide
N-(2-(2-(pyridin-2-yl)-1H-imidazol-1-yl)ethyl)furan-2-carboxamide
6-Bromo-1,4-dichloroisoquinoline
tert-butyl N-{3-[(1-aminocyclopropyl)methyl]-4-hydroxyphenyl}carbamate
2-(2,4-dichlorophenoxy)-N-(2-(2-(pyridin-2-yl)-1H-imidazol-1-yl)ethyl)acetamide
2,2a(2)-Bibenzo[1,2-d:4,5-da(2)]bisthiazole, 6,6a(2)-bis(3,5-dioctylphenyl)-

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