cis-4-Hydroxyproline

Suppliers

Names

[ Name ]:
cis-4-Hydroxyproline

[Synonym ]:
(2R,4R)-(+)-4-Hydroxy-2-pyrrolidinecarboxylic acid D-allo-Hydroxyproline
H-D-cis-Hyp-OH
(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic Acid
(4R)-4-Hydroxy-D-proline
cis-4-Hydroxyproline
D-cis-Hydroxyproline
(2R,4R)-(+)-4-Hydroxy-2-pyrrolidinecarboxylic acid
d-cis-4-hydroxyproline
cis-4-Hydroxy-D-proline
EINECS 219-963-5
MFCD00005252
D-Proline, 4-hydroxy-, (4R)-
D-allo-Hydroxyproline

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
355.2±42.0 °C at 760 mmHg

[ Melting Point ]:
243 °C (dec.)(lit.)

[ Molecular Formula ]:
C₅H₉NO₃

[ Molecular Weight ]:
131.130

[ Flash Point ]:
168.6±27.9 °C

[ Exact Mass ]:
131.058243

[ PSA ]:
69.56000

[ LogP ]:
-1.84

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.540

[ Water Solubility ]:
5 g/100 mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25-S22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

L-Hydroxyproline
(2R,4R,1'S)-1-(1'-phenylethyl)-4-hydroxy-proline methyl ester
N-Boc-cis-4-Hydroxy-D-proline
ethyl (4R)-2-(N-tert-butyloxycarbonylamino)-5-tert-butyldimethylsiloxy-2-pentenoate
(2R,4R)-4-<(tert-Butyl)dimethylsilyloxy>-2-cyanopyrrolidin-1-carbonsaeure-methylester
(R)-4-oxo-1,2-pyrrolidinedicarboxylic acid dimethyl ester
(2R,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester
(2R,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylic acid dimethyl ester

DownStream

(2R,4R)-TERT-BUTYL 4-HYDROXY-2-(HYDROXYMETHYL)PYRROLIDINE-1-CARBOXYLATE
Z-D-Cis-Hyp-OH
2-(r)-carboethoxy-4-(r)-hydroxypyrrolidine
D-Proline, 4-hydroxy-, methyl ester hydrochloride
cis-4-hydroxy-d-proline methyl ester
N-Boc-cis-4-Hydroxy-D-proline
(2R,4R)-n-Boc-2-(Fluoromethyl)-4-hydroxypyrrolidine
[(2R,4R)-4-(2,6-diaminopurin-9-yl)pyrrolidin-2-yl]methanol
(2S,4R)-METHYL 4-HYDROXYPYRROLIDINE-2-CARBOXYLATE
(R)-1-((BENZYLOXY)CARBONYL)-4-OXOPYRROLIDINE-2-CARBOXYLIC ACID

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Use of Commercial Dry Yeast Products Rich in Mannoproteins for White and Rosé Sparkling Wine Elaboration.

J. Agric. Food Chem. 63 , 5670-81, (2015)

In sparkling wines, mannoproteins released during yeast autolysis largely affect their final quality. This process is very slow and may take several months. The aim of this work was to study the effec...

Direct high-performance liquid chromatographic enantioseparation of secondary amino acids on Cinchona alkaloid-based chiral zwitterionic stationary phases. Unusual temperature behavior.

J. Chromatogr. A. 1363 , 169-77, (2014)

Two chiral stationary phases containing a quinine- or a quinidine-based zwitterionic ion-exchanger as chiral selector were applied for the enantioseparation of 27 unusual cyclic secondary α-amino acid...

Biological, biochemical and biomechanical characterisation of articular cartilage from the porcine, bovine and ovine hip and knee.

Biomed Mater Eng 25 , 381-95, (2015)

This study aimed to determine the optimal starting material for the development of an acellular osteochondral graft. Osteochondral tissues from three different species were characterised; pig (6 month...

cis-4-Hydroxyproline
4-cis-4-hydroxyproline
4-cis-4-hydroxyproline
cis-4-(trifluoromethoxy)cyclohexanecarboxylic acid
cis-4-Amino-1-(trifluoromethyl)cyclohexanol hydrochloride
cis-4-(tert-butyl)cyclohexylmethyl acetate
2-Anilino-1,1-dichloro-2-oxoethanesulfenyl chloride
Methyl 2-[4,5-dimethoxy-2-(piperidine-1-sulfonyl)phenyl]acetate
3-[[(2S)-1-Methyl-2-azetidinyl]methoxy]pyridine
N-cyano-N-methyl-3-(methylsulfanyl)aniline
4-(Ethylamino)-2,5-difluorobenzonitrile
4-(3-Chlorophenyl)butan-1-amine
(4R)-Ethyl 4-methyl-2-oxocyclohexanecarboxylate
5-(4-Fluorophenyl)-1,3-oxazole-2-carboxylic acid
Methylconiine, (R)-
Methyl 5-acetyl-2-methylfuran-3-carboxylate

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