1-Hydroxybenzotriazole

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Names

[ CAS No. ]:
2592-95-2

[ Name ]:
1-Hydroxybenzotriazole

[Synonym ]:
1H-Benzotriazol-1-ol
N-Hydroxybenzotrizole
hydroxybenzotriazole
HOBt solution
MFCD00005805
1-hydroxy-1H-1,2,3-benzotriazole
EINECS 219-989-7
1-hydroxy benzotriazole
1-Oxy-benztriazol
1,2,3-Benzotriazol-1-ol
N-hydroxy-benzotriazole
1H-1,2,3-Benzotriazole, 1-hydroxy-
1-hydroxy-1,2,3-benzotriazole
HOBTA
1-HOB
BENZOTRIAZOL-1-OL
HOBT
HBT
1-Hydroxybenzotriazole
1H-Benzo[d][1,2,3]triazol-1-ol
Benzazimidol
1-Methyl-2-pyrrolidinone

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
344.6±25.0 °C at 760 mmHg

[ Melting Point ]:
156-159°C

[ Molecular Formula ]:
C6H5N3O

[ Molecular Weight ]:
135.123

[ Flash Point ]:
162.2±23.2 °C

[ Exact Mass ]:
135.043259

[ PSA ]:
61.80000

[ LogP ]:
0.69

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.739

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable, but possible risk of explosion if heated under confinement. Flammable.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DM1288000
CHEMICAL NAME :
1H-Benzotriazole, 1-hydroxy-, hydrate
CAS REGISTRY NUMBER :
2592-95-2
BEILSTEIN REFERENCE NO. :
0004515
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C6-H5-N3-O
MOLECULAR WEIGHT :
135.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,679,1992 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,679,1992

Safety Information

[ Hazard Codes ]:
F:Flammable

[ Risk Phrases ]:
R11;R5

[ Safety Phrases ]:
S16-S33-S7/9-S26-S45-S53-S15

[ RIDADR ]:
1325

[ RTECS ]:
DM1288000

[ Packaging Group ]:
III

[ Hazard Class ]:
4.1

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • nitrobenzene
  • 2-Nitrochlorobenzene
  • 3,3-Difluorazetidinhydrochlorid(1:1)
  • HBTU
  • 4-Nitro-1H-pyrazole
  • 2-Nitrophenylhydrazine
  • 9-methoxy-2,3-dimethyl-9-phenyl-7H-8,9-dihydropyrano[2,3-c]imidazo[1,2-a]pyridine-6-carboxylic acid
  • methylamine
  • 1H-Benzotriazole,1-methoxy-

DownStream

  • Benzamide
  • 1H-Benzotriazole,1-methoxy-
  • α-Cumyl alcohol
  • 1,3-Butanediol,1,3-dibenzoate
  • 1H-Benzo[d][1,2,3]triazol-1-yl 4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzoate
  • Fmoc-OBT
  • 4-TERT-BUTOXYCARBONYLAMINO-1-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID BENZOTRIAZOL-1YL ESTER
  • 1,1'-[Carbonylbis(oxy)]bis(1H-benzotriazole)
  • 1-Methylbenzotriazole

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 1-Hydroxybenzotriazole
  • 1-hydroxybenzotriazole
  • 7-Aza-1-hydroxybenzotriazole
  • 1-hydroxybenzotriazole,hydrate
  • AMMONIUM1-HYDROXYBENZOTRIAZOLE
  • 6-nitro-1-hydroxybenzotriazole
  • Ethyl 1,4-oxazepane-5-carboxylate
  • Methyl 5-isobutoxy-4-methoxypicolinate
  • 2,2-Difluoro-1-(4-methylthiophen-3-yl)ethan-1-amine
  • Methyl 1-(4-piperidinyl)-1H-imidazole-5-carboxylate
  • Methyl 4-(aminomethyl)-5-chlorothiophene-2-carboxylate
  • Ethyl 4,4-difluoro-5-oxocycloheptane-1-carboxylate
  • 2-(2-(Aminomethyl)cyclohexyl)isothiazolidine 1,1-dioxide acetate
  • Methyl 2-bromo-3-cyano-5-fluorophenylacetate
  • 4,4,5,5-Tetramethyl-2-[(Z)-3,3,3-trifluoro-2-phenylprop-1-enyl]-1,3,2-dioxaborolane
  • Lithium(1+) ion 3-(difluoromethoxy)-4-fluorobenzene-1-sulfinate
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