Minaprine (dihydrochloride)

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Names

[ CAS No. ]:
25953-17-7

[ Name ]:
Minaprine (dihydrochloride)

[Synonym ]:
Ag 620
Agr 620
Pyridazine, 4-methyl-3-[(2-morpholinoethyl)amino]-6-phenyl-, dihydrochloride
Agr 1240
4-Morpholineethanamine,N-(4-methyl-6-phenyl-3-pyridazinyl)-,dihydrochloride
Morpholine,4-[2-[(4-methyl-6-phenyl-3-pyridazinyl)amino]ethyl]-,dihydrochloride
Minaprine (dihydrochloride)

Chemical & Physical Properties

[ Boiling Point ]:
531.2ºC at 760 mmHg

[ Molecular Formula ]:
C17H24Cl2N4O

[ Molecular Weight ]:
371.30

[ Flash Point ]:
275.1ºC

[ PSA ]:
50.28000

[ LogP ]:
3.00900

[ Vapour Pressure ]:
2.29E-11mmHg at 25°C

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QE3477835
CHEMICAL NAME :
4-Morpholineethanamine, N-(4-methyl-6-phenyl-3-pyridazinyl)-, dihydrochloride
CAS REGISTRY NUMBER :
25953-17-7
LAST UPDATED :
199707
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C17-H22-N4-O.2Cl-H
MOLECULAR WEIGHT :
371.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,824,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
63 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4508720 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4823 mg/kg/13W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight Endocrine - changes in thymus weight
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,1894,1990

Related Compounds

  • Minaprine
  • 4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine,hydrochloride
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  • Benzylhydrazine dihydrochloride
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  • 1-Bromo-2-(bromomethyl)-3,3-dimethylbutane
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