9(S)-Erythromycylamine

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Names

[ CAS No. ]:
26116-56-3

[ Name ]:
9(S)-Erythromycylamine

[Synonym ]:
MFCD00872156

Chemical & Physical Properties

[ Density]:
1.19g/cm3

[ Boiling Point ]:
810.3ºC at 760mmHg

[ Molecular Formula ]:
C₃₇H₇₀N₂O₁₂

[ Molecular Weight ]:
734.96

[ Flash Point ]:
443.8ºC

[ Exact Mass ]:
734.49300

[ PSA ]:
202.86000

[ LogP ]:
2.24410

[ Vapour Pressure ]:
2.15E-30mmHg at 25°C

[ Index of Refraction ]:
1.539

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KF4590000

CHEMICAL NAME :: Erythromycin, 9-amino-9-deoxo-, stereoisomer

CAS REGISTRY NUMBER :: 26116-56-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C37-H70-N2-O12

MOLECULAR WEIGHT :: 735.09

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,83,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,83,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 57500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,83,1978

Safety Information

[ Hazard Codes ]:
Xi,N

[ Risk Phrases ]:
41-50/53

[ Safety Phrases ]:
26-39-60-61

Precursor & DownStream

Precursor

α-[2]naphthylamino-deoxybenzoin
4-acetyl-L-cladinose
(2S,3R,4S,6R)-4-(dimethylamino)-6-methyl-2-(pyrimidin-2-ylthio)tetrahydro-2H-pyran-3-yl methyl carbonate
N-((2R,3S,4R,5S,6S,7R,9R,10R,11S,12S,13R)-2-ethyl-3,4,9,10,12-pentahydroxy-3,5,7,9,11,13-hexamethyl-14-oxooxacyclotetradecan-6-yl)-[1,1'-biphenyl]-4-carboxamide
N-((1S,2R,5R,6S,7R,8S,9S,10R,12R,13R,15R,17S)-5-ethyl-6,7,12-trihydroxy-15-mesityl-2,6,8,10,12,17-hexamethyl-3-oxo-4,14,16-trioxabicyclo[11.3.1]heptadecan-9-yl)-[1,1'-biphenyl]-4-carboxamide
N-((2R,3S,4R,5S,6S,7R,9R,10R,11S,12S,13R)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,9,12-tetrahydroxy-3,5,7,9,11,13-hexamethyl-14-oxooxacyclotetradecan-6-yl)-[1,1'-biphenyl]-4-carboxamide