Pregna-4,11-Diene-3,20-Dione

Names

[ CAS No. ]:
2625-60-7

[ Name ]:
Pregna-4,11-Diene-3,20-Dione

[Synonym ]:
Pregna-4,11-dien-3,20-dion
Pregna-4,11-Diene-3,20-Dione
3,20-Dioxo-pregna-4,11-dien
11-Dehydroprogesterone
delta11-Progesterone
11-Dehydro-progesteron
UNII-YUL6GTR69Y

Chemical & Physical Properties

[ Density]:
1.1g/cm3

[ Boiling Point ]:
451.5ºC at 760mmHg

[ Molecular Formula ]:
C21H28O2

[ Molecular Weight ]:
312.44600

[ Flash Point ]:
168.2ºC

[ Exact Mass ]:
312.20900

[ PSA ]:
34.14000

[ LogP ]:
4.49950

[ Vapour Pressure ]:
2.43E-08mmHg at 25°C

[ Index of Refraction ]:
1.556

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU3670000
CHEMICAL NAME :
Pregna-4,11-diene-3,20-dione
CAS REGISTRY NUMBER :
2625-60-7
BEILSTEIN REFERENCE NO. :
3219163
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C21-H28-O2
MOLECULAR WEIGHT :
312.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
50 umol/L
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 146,401,1974

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Pregn-11-ene-3,20-dione,(5b)- (9CI)
  • Pregn-4-ene-3,20-dione,11-hydroxy-, (11α)-
  • 12α-(toluene-4-sulfonyloxy)-pregn-4-ene-3,20-dione
  • Tosyl chloride
  • 2,4,6-Trimethylpyridine
  • 11α-hydroxyprogesterone toluene-p-sulphonate
  • 12α-acetoxy-pregn-4-ene-3,20-dione

DownStream

  • 11β,12β-epoxy-pregn-4-ene-3,20-dione

Related Compounds

  • Pregna-4,9(11)-diene-3,20-dione,12-methyl-, (12a)- (9CI)
  • 10α-Pregna-4,9(11)-diene-3,20-dione, 17,21-dihydroxy-, 21-acetate (7CI,8CI)
  • 21-bromo-17-hydroxy-pregna-4,9(11)-diene-3,20-dione
  • 21-chloro-17-hydroxy-pregna-4,9(11)-diene-3,20-dione
  • 21-diazo-16α,17-epoxy-pregna-4,9(11)-diene-3,20-dione
  • 4,9(11)-PREGNADIEN-3,20-DIONE
  • 1-(2-Hydroxy-2-methyl-3-(methylthio)propyl)-3-phenethylurea
  • N-(2-(2-(1H-pyrazol-1-yl)thiazol-4-yl)ethyl)methanesulfonamide
  • 3-Fluoro-4-(methylsulfamoyl)benzoic acid
  • N-(3,5-dimethoxyphenyl)-5-(4-fluoroanilino)triazolidine-4-carboxamide
  • N-(4-fluoro-2-methylphenyl)-5-(4-methylanilino)triazolidine-4-carboxamide
  • N-(2,5-diethoxyphenyl)-5-(4-methoxyanilino)triazolidine-4-carboxamide
  • 5-(3-chloroanilino)-N-(2,5-diethoxyphenyl)triazolidine-4-carboxamide
  • N-{[4-(1H-1,3-benzodiazol-2-yl)cyclohexyl]methyl}-3-(furan-2-yl)-1H-pyrazole-5-carboxamide
  • (3aR*,9bR*)-2-acetyl-1,2,3,9b-tetrahydrochromeno[3,4-c]pyrrole-3a(4H)-carboxylic acid
  • 2-(5-(Difluoromethyl)-2-fluorophenyl)pyrrolidine
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