2,4-Dihydroxy-5,6-dimethylpyrimidine

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Names

[ CAS No. ]:
26305-13-5

[ Name ]:
2,4-Dihydroxy-5,6-dimethylpyrimidine

[Synonym ]:
5,6-dimethylpyrimidine-2,4-dione
2,4-Dihydroxy-5,6-dimethylpyrimidine
5,6-Dimethyl-2,4(1H,3H)-pyrimidinedione
5,6-dimethylpyrimidine-2,4-diol
5,6-DIMETHYLURACIL
5,6-Dimethylpyrimidine-2,4(1H,3H)-dione
2,4(1H,3H)-Pyrimidinedione, 5,6-dimethyl-
EINECS 247-601-6
Uracil,5,6-dimethyl
5,6-dimethyl-2,4-(1H,3H)-pyrimidinedione
MFCD00010708
6-Methylthymine
5,6-Dimethyl-2,4-pyrimidinediol

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
408.8ºC at 760mmHg

[ Melting Point ]:
297-300 °C (dec.)(lit.)

[ Molecular Formula ]:
C6H8N2O2

[ Molecular Weight ]:
140.140

[ Flash Point ]:
201ºC

[ Exact Mass ]:
140.058578

[ PSA ]:
65.72000

[ LogP ]:
0.47

[ Vapour Pressure ]:
2.88E-07mmHg at 25°C

[ Index of Refraction ]:
1.482

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YQ9750000
CHEMICAL NAME :
Uracil, 5,6-dimethyl-
CAS REGISTRY NUMBER :
26305-13-5
LAST UPDATED :
199206
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C6-H8-N2-O2
MOLECULAR WEIGHT :
140.16
WISWESSER LINE NOTATION :
T6MVMVJ E1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
140 mg/kg
TOXIC EFFECTS :
Behavioral - antipsychotic
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 6,490,1958

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
YQ9750000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethyl 2-methylacetoacetate
  • Urea
  • 5,6-dimethyl-2-Thiouracil
  • 1,3-dibenzyl-5,6-dimethyl-1H-pyrimidine-2,4-dione
  • 5,6-Dimethyl-4-hydroxy-2-methoxypyrimidine
  • 3-(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)propanoate
  • 6-Methyluracil
  • cyanic acid

DownStream

  • 4-Pyrimidinecarboxaldehyde,1,2,3,6-tetrahydro-5-methyl-2,6-dioxo-
  • acetylurea
  • Oxalic acid
  • 1-acetyl-5-hydroxy-5-methylhydantoin
  • 5-Hydroxy-5-methylhydantoin
  • 2,4-Dichloro-5,6-dimethylpyrimidine
  • 2,4-dimethoxy-5,6-dimethylpyrimidine

Articles

Novel pyrimidines as acid pump antagonists (APAs).

Bioorg. Med. Chem. Lett. 20(19) , 5735-8, (2010)

A series of pyrimidine derivatives as acid pump antagonists (APAs) was synthesized and the inhibitory activities against H(+)/K(+) ATPase isolated from hog gastric mucosa were determined. After elabor...

A family of titanium (IV) alkoxo complexes with N, O and O, O chelating ligands. Crystal structure of [Ti (O-i-Pr)2{2-(-)-menthoxo-pyridine}2]. Pérez Y, et al.

Inorganica Chim. Acta 360(2) , 607-618, (2007)


More Articles

Related Compounds

  • 2,4-dihydroxy-5,6,7,8,8a,10-hexahydro-4bH-phenanthren-9-one
  • ethyl 2,4-dihydroxy-5,6,7,8-tetrahydroquinazoline-6-carboxylate
  • Ethyl 2,4-dihydroxy-5,6-dimethylnicotinate
  • methyl 3-formyl-2,4-dihydroxy-5,6-dimethylbenzoate
  • Methyl 4,6-Dihydroxy-2,3-dimethylbenzoate
  • 4-(6'-methoxy-2'-benzothiazolylazo)resacetophenone oxime
  • N-(cyanomethyl)-2,6-dimethylquinoline-3-carboxamide
  • N-(cyanomethyl)-3-({6-methylimidazo[1,2-a]pyridin-2-yl}methoxy)benzamide
  • N-(cyanomethyl)-1-[3-(trifluoromethyl)phenyl]cyclopentane-1-carboxamide
  • N-(cyanomethyl)-2-(1H-pyrrol-1-yl)-4H,5H,7H-thieno[2,3-c]thiopyran-3-carboxamide
  • 5-((2-(Thiophen-2-yl)ethyl)thio)-1,3,4-thiadiazol-2-amine
  • 2,6-dichloro-N-methyl-N-(4-phenoxyphenyl)pyridine-3-carboxamide
  • N-(cyanomethyl)-2-{[4-(piperidin-1-yl)phenyl]sulfamoyl}acetamide
  • N-(cyanomethyl)-2-(2,4-dimethylphenyl)-4-methyl-1,3-thiazole-5-carboxamide
  • N-(cyanomethyl)-3-phenyl-5H,6H,7H,8H,9H-imidazo[1,5-a]azepine-1-carboxamide
  • 1-(3-chlorophenyl)-N-(cyanomethyl)-5-ethyl-1H-pyrazole-4-carboxamide
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