1H-Pyrrolizine-7-methanol,2,3-dihydro-1-hydroxy-, (1S)-

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Names

[ CAS No. ]:
26400-24-8

[ Name ]:
1H-Pyrrolizine-7-methanol,2,3-dihydro-1-hydroxy-, (1S)-

[Synonym ]:
Dehydroheliotridin
3,8a-Didehydroheliotridine
Heliotridine,8-didehydro
dehydroheliotridine
3,8-Dehydroheliotridine

Chemical & Physical Properties

[ Density]:
1.39g/cm3

[ Boiling Point ]:
361.2ºC at 760 mmHg

[ Molecular Formula ]:
C8H11NO2

[ Molecular Weight ]:
153.17800

[ Flash Point ]:
172.3ºC

[ Exact Mass ]:
153.07900

[ PSA ]:
45.39000

[ LogP ]:
0.41750

[ Vapour Pressure ]:
7.54E-06mmHg at 25°C

[ Index of Refraction ]:
1.65

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UY8350000
CHEMICAL NAME :
1H-Pyrrolizine-7-methanol, 2,3-dihydro-1-hydroxy-, (S)-
CAS REGISTRY NUMBER :
26400-24-8
LAST UPDATED :
199012
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C8-H11-N-O2
MOLECULAR WEIGHT :
153.20
WISWESSER LINE NOTATION :
T55 AN&TJ D1Q FQ -S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
92 mg/kg
TOXIC EFFECTS :
Liver - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
40 mg/kg
SEX/DURATION :
female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
60 mg/kg
SEX/DURATION :
female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
30 mg/kg
SEX/DURATION :
female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
40 mg/kg
SEX/DURATION :
female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Mammal - species unspecified Leukocyte
DOSE/DURATION :
500 nmol/L
REFERENCE :
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 3,245,1971

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 7α-Hydroxy-6,7-dihydro-pyrrolizin-1-carbaldehyd

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 1-[3-Amino-4-(trifluoromethyl)piperidin-1-yl]-4-(2,5-dimethylthiophen-3-yl)butan-1-one hydrochloride
  • [1-(2,3-Dihydro-1-benzofuran-7-yl)-4,4-difluorocyclohexyl]methanamine
  • 1-[4-(Aminomethyl)-4-phenylpiperidin-1-yl]-2-(2,3-dihydro-1,4-benzodioxin-5-yl)ethanone;hydrochloride
  • 1-[1-({2,3-Dihydrospiro[1-benzopyran-4,1'-cyclopropan]-3'-yl}carbonyl)-4-phenylpiperidin-4-yl]methanamine hydrochloride
  • Tert-butyl 4-{3-[(fluorosulfonyl)methyl]-5-iodo-2-methylphenyl}piperazine-1-carboxylate
  • Tert-butyl 4-{[5-(fluorosulfonyl)-3-iodo-2-methylphenyl]methyl}piperazine-1-carboxylate
  • tert-butyl 2-[5-azido-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-2-methylphenyl]acetate
  • tert-butyl 2-[3-azido-5-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-4-methylphenyl]acetate
  • methyl 2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-2-methyl-5-(piperazin-1-yl)phenyl]acetate
  • methyl 2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-4-methyl-5-(piperazin-1-yl)phenyl]acetate
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